2632-78-2

Basic information

• Product Name: chloro(chloromethyl)diphenylsilane
• Synonyms: chloro(chloromethyl)diphenylsilane
• CAS NO: 2632-78-2
• Molecular Weight: 267.23
• Mol File: 2632-78-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: chloro(chloromethyl)diphenylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: chloro(chloromethyl)diphenylsilane(2632-78-2)
• EPA Substance Registry System: chloro(chloromethyl)diphenylsilane(2632-78-2)

Safety Data

• Hazardous Substances Data: 2632-78-2(Hazardous Substances Data)

Upstream product

• 18080-97-2 (chloromethyl)diphenylsilane 
• 1558-25-4 (chloromethyl)trichlorosilane 
• 100-59-4 phenylmagnesium chloride 

Downstream Products

• 84440-49-3 Acetoxy(acetoxymethyl)diphenylsilan 
• 1360471-29-9 ethyl(iodomethyl)diphenylsilane 
• 1360471-30-2 ethyl[(S)-2-(methoxymethyl)pyrrolidinomethyl]diphenylsilane 
• 84606-53-1 Deuteriomethyl<2-(dimethylamino)ethoxy>diphenylsilan 
• 84606-52-0 <2-(Dimethylamino)ethylthiomethyl>diphenylsilan 
• 84606-54-2 (Iodmethyl)diphenylsilan 
• 57665-45-9 <2-(Dimethylamino)ethoxy>methyldiphenylsilan 
• 84440-50-6 (Hydroxymethyl)diphenylsilan 
• 439869-07-5 (iodomethyl)diphenyl(p-trifluoromethylphenyl)silane 
• 439869-11-1 [(p-dimethylamino)phenyl](iodomethyl)diphenylsilane 
• 439869-10-0 (iodomethyl)(p-methoxyphenyl)diphenylsilane 
• 439869-09-7 (iodomethyl)(p-methylphenyl)diphenylsilane 
• 439869-08-6 (p-chlorophenyl)(iodomethyl)diphenylsilane 
• 561294-36-8 (S)-2-[(S)-2-[[[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]diphenylsilanyl]methyl]-4-methylpentanoylamino]-4-methylpentanoic acid tert-butyl ester 

Relevant articles and documents

Silanediol-based inhibitor of thermolysin

The first silanediol inhibitor of thermolysin is reported, prepared by analogy with the Grobelny/Bartlett phosphinate inhibitor. A Cbz group on nitrogen proved to be unstable to the triflic acid mediated silanediol deprotection and was replaced with a dihydrocinnamoyl group. The silanediol was prepared in high purity by hydrolysis of a difluorosilane intermediate and proved to be an effective inhibitor, differing from the phosphinate by a factor of 4 (Ki=41 nM).

Synthesis and Properties of (Hydroxymethyl)diorganylsilanes

The synthesis of the (hydroxymethyl)diorganylsilanes R1R2Si(H)CH2OH (4a: R1 = R2 = CH3, 2-silaisobutanol; 4b: R1 = CH3, R2 = C6H5; 4c: R1 = R2 = C6H5) is achieved by the reaction of R1R2Si(Cl)CH2Cl (2a - c) with AcOH/NEt3 to R1R2Si(OAc)CH2OAc (3a - c), fo