(1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol

Base Information

• Chemical Name: (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol
• CAS No.: 915725-67-6
• Molecular Formula: C₃₁H₃₇NO₂
• Molecular Weight: 455.64

Synonyms:(1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol

Chemical Property of (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol

Chemical Property:

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Safty Information:

• Pictogram(s):  
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Technology Process of (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol

There total 6 articles about (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-((2S,3S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-benzaldehyde (865262-74-4) + phenyllithium (591-51-5) → (1S,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol + (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol (915725-67-6)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 0.75h;

DOI:10.1016/j.tet.2006.08.058

Reference yield: 94.0%

2-((2S,3S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-benzaldehyde (865262-74-4) + phenylmagnesium bromide → (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol (915725-67-6)

Guidance literature:

With cerium(III) chloride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1016/j.tet.2006.08.058

Reference yield:

(2S,4aS,7R,8aR)-3-benzyl-2-(2-bromophenyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazine (915725-70-1) + benzaldehyde (100-52-7) → (1S,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol + (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol (915725-67-6)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; at -90 ℃;

DOI:10.1016/j.tet.2006.08.058

upstream raw materials:

(2S,4aS,7R,8aR)-3-benzyl-2-(2-bromophenyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazine

benzaldehyde

2-((2S,3S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-benzaldehyde

phenyllithium

Downstream raw materials:

3‐phenylisobenzofuran‐1(3H)‐one

(R)-1-Ethoxy-3-phenyl-1,3-dihydro-isobenzofuran

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