N-(6-fluoro-3-hydroxy-2-methylphenyl)-3-(3-fluorophenyl)-5-methoxybenzamide

Base Information

Chemical Name:N-(6-fluoro-3-hydroxy-2-methylphenyl)-3-(3-fluorophenyl)-5-methoxybenzamide
CAS No.:1427407-99-5
Molecular Formula:C₂₁H₁₆F₃NO₂
Molecular Weight:371.359
Hs Code.:

Synonyms:N-(6-fluoro-3-hydroxy-2-methylphenyl)-3-(3-fluorophenyl)-5-methoxybenzamide

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Chemical Property of N-(6-fluoro-3-hydroxy-2-methylphenyl)-3-(3-fluorophenyl)-5-methoxybenzamide

Chemical Property:

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Technology Process of N-(6-fluoro-3-hydroxy-2-methylphenyl)-3-(3-fluorophenyl)-5-methoxybenzamide

There total 10 articles about N-(6-fluoro-3-hydroxy-2-methylphenyl)-3-(3-fluorophenyl)-5-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 364328-07-4
2-methyl-3-hydroxy-6-fluoroaniline

: C₁₄H₉ClF₂O

: 1427407-99-5
N-(6-fluoro-3-hydroxy-2-methylphenyl)-3-(3-fluorophenyl)-5-methoxybenzamide

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

: 1227210-35-6
1-bromo-4-fluoro-2-methyl-3-nitro-benzene

: 1427407-99-5
N-(6-fluoro-3-hydroxy-2-methylphenyl)-3-(3-fluorophenyl)-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: iron; ammonium chloride / ethanol / 3 h / Reflux

2: dmap; triethylamine / N,N-dimethyl-formamide

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

4: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

5: trifluoroacetic acid / dichloromethane / 20 °C

6: potassium carbonate / tetrahydrofuran / 3 h / 0 - 20 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; dihydrogen peroxide; potassium acetate; iron; potassium carbonate; ammonium chloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1227210-36-7
3-bromo-6-fluoro-2-methyl-aniline

: 1427407-99-5
N-(6-fluoro-3-hydroxy-2-methylphenyl)-3-(3-fluorophenyl)-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; triethylamine / N,N-dimethyl-formamide

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

3: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

5: potassium carbonate / tetrahydrofuran / 3 h / 0 - 20 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; dihydrogen peroxide; potassium acetate; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;