N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-hydroxypropyl)-2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxamide

Base Information

Chemical Name:N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-hydroxypropyl)-2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxamide
CAS No.:1261175-24-9
Molecular Formula:C₂₅H₂₉Cl₂N₅O₂
Molecular Weight:502.444
Hs Code.:

Synonyms:N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-hydroxypropyl)-2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxamide

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Chemical Property of N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-hydroxypropyl)-2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxamide

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Technology Process of N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-hydroxypropyl)-2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxamide

There total 5 articles about N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-hydroxypropyl)-2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1220951-01-8
2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-oxopropyl)isoindoline-1,3-dione

: 1261181-06-9
lithium 2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxylate

: 1261175-24-9
N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-hydroxypropyl)-2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1261181-07-0
ethyl 2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxylate

: 1261175-24-9
N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-hydroxypropyl)-2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / water; tetrahydrofuran / 12 h / 55 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 5431-93-6
ethyl 2-(acetylamino)-3-oxobutanoate

: 1261175-24-9
N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-hydroxypropyl)-2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / propyl cyanide / 0.67 h / 140 °C / microwave irradiation; Inert atmosphere

2: lithium hydroxide monohydrate / water; tetrahydrofuran / 12 h / 55 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; propyl cyanide; water; N,N-dimethyl-formamide;