2-(8-Azaspiro[4.5]dec-8-yl)benzophenon

Base Information

• Chemical Name: 2-(8-Azaspiro[4.5]dec-8-yl)benzophenon
• CAS No.: 291544-98-4
• Molecular Formula: C₂₂H₂₅NO
• Molecular Weight: 319.447
• Mol file: 291544-98-4.mol

Synonyms:2-(8-Azaspiro[4.5]dec-8-yl)benzophenon

Chemical Property of 2-(8-Azaspiro[4.5]dec-8-yl)benzophenon

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(8-Azaspiro[4.5]dec-8-yl)benzophenon

There total 1 articles about 2-(8-Azaspiro[4.5]dec-8-yl)benzophenon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

8-azaspiro[4.5]decane (176-64-7) + o-fluorobenzophenone (342-24-5) → 2-(8-Azaspiro[4.5]dec-8-yl)benzophenon (291544-98-4)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 85 - 90 ℃;

Reference yield: 92.0%

2-(8-Azaspiro[4.5]dec-8-yl)benzophenon (291544-98-4) → α-[2-(8-Azaspiro[4.5]dec-8-yl)phenyl]benzylalkohol (291544-76-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol;

Reference yield:

2-(8-Azaspiro[4.5]dec-8-yl)benzophenon (291544-98-4) → 8-[2-(α-Hydroxybenzyl)phenyl]-8-azaspiro[4.5]decan-7-on

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / NaBH₄ / ethanol

2: 41 percent / HgO; disodium ethylenediaminetetraacetate dihydrate / H₂O; ethanol / 3 h / Heating

With sodium tetrahydroborate; edetate disodium dihydrate; mercury(II) oxide; In ethanol; water; 1: Reduction / 2: Oxidation;

upstream raw materials:

8-azaspiro[4.5]decane

o-fluorobenzophenone

Downstream raw materials:

α-[2-(8-Azaspiro[4.5]dec-8-yl)phenyl]benzylalkohol

Refernces