C₁₈H₂₁BrN₄O₃

Base Information

• Chemical Name: C₁₈H₂₁BrN₄O₃
• CAS No.: 1313913-32-4
• Molecular Formula: C₁₈H₂₁BrN₄O₃
• Molecular Weight: 421.294
• Mol file: 1313913-32-4.mol

Synonyms:C₁₈H₂₁BrN₄O₃

Chemical Property of C₁₈H₂₁BrN₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₁BrN₄O₃

There total 4 articles about C₁₈H₂₁BrN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-methyl-4-hydroxypiperidine (106-52-5) + C12H10BrN3O3 (1313913-27-7) → C18H21BrN4O3 (1313913-32-4)

Guidance literature:

With di-tert-butyl-diazodicarboxylate; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/co200062n

Reference yield:

Methyl 3-amino-2-pyrazinecarboxylate (16298-03-6) → C18H21BrN4O3 (1313913-32-4)

Guidance literature:

Multi-step reaction with 4 steps

1: bromine; sodium acetate / acetic acid / 20 °C

2: hydrogen bromide; bromine; sodium nitrite / water; acetic acid / 0.83 h / 0 - 5 °C

3: methanol / 1 h / 100 °C

4: di-tert-butyl-diazodicarboxylate / dichloromethane / 0.5 h / 20 °C

With di-tert-butyl-diazodicarboxylate; hydrogen bromide; bromine; sodium acetate; sodium nitrite; In methanol; dichloromethane; water; acetic acid; 2: Sandmeyer reaction / 4: Mitsunobu reaction;

DOI:10.1021/co200062n

Reference yield:

methyl 3-amino-6-bromopyrazine-2-carboxylate (6966-01-4) → C18H21BrN4O3 (1313913-32-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide; bromine; sodium nitrite / water; acetic acid / 0.83 h / 0 - 5 °C

2: methanol / 1 h / 100 °C

3: di-tert-butyl-diazodicarboxylate / dichloromethane / 0.5 h / 20 °C

With di-tert-butyl-diazodicarboxylate; hydrogen bromide; bromine; sodium nitrite; In methanol; dichloromethane; water; acetic acid; 1: Sandmeyer reaction / 3: Mitsunobu reaction;

DOI:10.1021/co200062n

upstream raw materials:

N-methyl-4-hydroxypiperidine

C₁₂H₁₀BrN₃O₃

Methyl 3-amino-2-pyrazinecarboxylate

methyl 3-amino-6-bromopyrazine-2-carboxylate

Downstream raw materials:

C₂₃H₂₆N₆O₃

C₂₃H₂₅N₅O₃

C₂₄H₂₇N₅O₃

C₂₄H₂₆N₄O₄