10-deacetyl-9(R)-dihydro-10-triethylsilyl-2'-tert-butyldimethylsilyl-1-deoxypaclitaxel 7,9-acetonide

Base Information

Chemical Name:10-deacetyl-9(R)-dihydro-10-triethylsilyl-2'-tert-butyldimethylsilyl-1-deoxypaclitaxel 7,9-acetonide
CAS No.:205490-21-7
Molecular Formula:C₆₀H₈₃NO₁₂Si₂
Molecular Weight:1066.49
Hs Code.:

Synonyms:10-deacetyl-9(R)-dihydro-10-triethylsilyl-2'-tert-butyldimethylsilyl-1-deoxypaclitaxel 7,9-acetonide

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Chemical Property of 10-deacetyl-9(R)-dihydro-10-triethylsilyl-2'-tert-butyldimethylsilyl-1-deoxypaclitaxel 7,9-acetonide

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Technology Process of 10-deacetyl-9(R)-dihydro-10-triethylsilyl-2'-tert-butyldimethylsilyl-1-deoxypaclitaxel 7,9-acetonide

There total 5 articles about 10-deacetyl-9(R)-dihydro-10-triethylsilyl-2'-tert-butyldimethylsilyl-1-deoxypaclitaxel 7,9-acetonide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: (3R,4S)-1-Benzoyl-3-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-azetidin-2-one

: 205490-20-6
7,9,10,13-tetradeacetyl-10-triethylsilylbaccatin VI 7,9-acetonide

: 205490-21-7
10-deacetyl-9(R)-dihydro-10-triethylsilyl-2'-tert-butyldimethylsilyl-1-deoxypaclitaxel 7,9-acetonide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;
DOI:10.1021/jo981406l

Reference yield:

: 994-30-9
triethylsilyl chloride

: 205490-21-7
10-deacetyl-9(R)-dihydro-10-triethylsilyl-2'-tert-butyldimethylsilyl-1-deoxypaclitaxel 7,9-acetonide

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / imidazole / CH₂Cl₂ / 2 h / Ambient temperature

2: 63 percent / MeLi / tetrahydrofuran; diethyl ether / 0.17 h / -78 °C

3: 23 percent / n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

With 1H-imidazole; n-butyllithium; methyllithium; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo981406l

Reference yield:

: 205490-17-1
7,9,10-trideacetyl-1-deoxybaccatin VI

: 205490-21-7
10-deacetyl-9(R)-dihydro-10-triethylsilyl-2'-tert-butyldimethylsilyl-1-deoxypaclitaxel 7,9-acetonide

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / PPTS / CH₂Cl₂ / 12 h / Ambient temperature

2: 74 percent / imidazole / CH₂Cl₂ / 2 h / Ambient temperature

3: 63 percent / MeLi / tetrahydrofuran; diethyl ether / 0.17 h / -78 °C

4: 23 percent / n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

With 1H-imidazole; n-butyllithium; methyllithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo981406l