(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

Base Information

Chemical Name:(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453851-79-0
Molecular Formula:C₂₄H₂₉ClFN₃O₂SSi
Molecular Weight:506.116
Hs Code.:

Synonyms:(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of (S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of (S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

There total 18 articles about (S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1453851-59-6
(R)-2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl methanesulfonate

: 1453851-57-4
4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

: 1453851-79-0
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: 4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one; With potassium hexamethylsilazane; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; at 25 - 40 ℃; for 3h; Large scale;

(R)-2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl methanesulfonate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; at 40 - 90 ℃; for 6h; regioselective reaction; Large scale;
DOI:10.1021/acs.oprd.7b00006

Reference yield:

: 1453854-84-6
(R)-1-(4-chloro-3-fluorophenyl)ethane-1,2-diol

: 1453851-79-0
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

2.1: triethylamine / dichloromethane / 0.5 h / 0 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

3.2: 30 h / 20 °C

With 1H-imidazole; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1395078-43-9
(R)-2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethanol

: 1453851-79-0
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.5 h / 0 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

2.2: 30 h / 20 °C

With potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; dichloromethane;