(S)-1-(2-(tert- butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4- yl)pyridin-2(1H)-one

Base Information

Chemical Name:(S)-1-(2-(tert- butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4- yl)pyridin-2(1H)-one
CAS No.:1453851-69-8
Molecular Formula:C₂₄H₂₉ClFN₃O₄SSi
Molecular Weight:538.115
Hs Code.:
Mol file:1453851-69-8.mol

Synonyms:(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)-pyridin-2(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(2-(tert- butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4- yl)pyridin-2(1H)-one

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (S)-1-(2-(tert- butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4- yl)pyridin-2(1H)-one

There total 19 articles about (S)-1-(2-(tert- butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4- yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1453851-79-0
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

: 1453851-69-8
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)-pyridin-2(1H)-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 1453854-84-6
(R)-1-(4-chloro-3-fluorophenyl)ethane-1,2-diol

: 1453851-69-8
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)-pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

2.1: triethylamine / dichloromethane / 0.5 h / 0 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

3.2: 30 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

With 1H-imidazole; potassium hexamethylsilazane; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1395078-43-9
(R)-2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethanol

: 1453851-69-8
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)-pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.5 h / 0 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

2.2: 30 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

With potassium hexamethylsilazane; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;