(S)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-4-methoxyaniline

Base Information

• Chemical Name: (S)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-4-methoxyaniline
• CAS No.: 1334287-95-4
• Molecular Formula: C₁₅H₁₃BrF₃NO
• Molecular Weight: 360.174
• Mol file: 1334287-95-4.mol

Synonyms:(S)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-4-methoxyaniline

Chemical Property of (S)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-4-methoxyaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (S)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-4-methoxyaniline

There total 4 articles about (S)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-4-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,4,6-tris(4-bromophenyl)boroxin (7519-94-0) + N-(2,2,2-trifluoroethylidene)-4-methoxyaniline (99333-34-3) → (S)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-4-methoxyaniline (1334287-95-4)

Guidance literature:

With silver tetrafluoroborate; [(pyridinooxazoline)PdCl₂]; In 1,2-dichloro-ethane; at 65 ℃; for 20h; Reagent/catalyst; enantioselective reaction; Molecular sieve;

DOI:10.1021/acs.joc.6b00657

Reference yield: 89.0%

N-(1-(4-bromophenyl)-2,2,2-trifluoroethylidene)-4-methoxyaniline (1210049-13-0) → (S)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-4-methoxyaniline (1334287-95-4)

Guidance literature:

With (R)-3,3'-bis[3,5-di(trifluoromethyl)phenyl]-1,1'-binaphthyl phosphate; 2-(4-nitrophenyl)-2,3-dihydrobenzothiazole; In dichloromethane; at 55 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201103240

Reference yield: 85.0%

N-(2,2,2-trifluoro-1-methoxyethyl)-4-methoxyaniline (1005385-31-8) + 2,4,6-tris(4-bromophenyl)boroxin (7519-94-0) → (S)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-4-methoxyaniline (1334287-95-4)

Guidance literature:

With silver tetrafluoroborate; [(pyridinooxazoline)PdCl₂]; In 1,2-dichloro-ethane; at 65 ℃; for 20h; enantioselective reaction;

DOI:10.1021/acs.joc.6b00657

upstream raw materials:

N-(1-(4-bromophenyl)-2,2,2-trifluoroethylidene)-4-methoxyaniline

4'-bromo-2,2,2-trifluoroacetophenone

4-methoxy-N-(triphenylphosphoran-ylidene)-aniline

2,4,6-tris(4-bromophenyl)boroxin