N-(1-(4-bromophenyl)-2,2,2-trifluoroethylidene)-4-methoxyaniline

Base Information

• Chemical Name: N-(1-(4-bromophenyl)-2,2,2-trifluoroethylidene)-4-methoxyaniline
• CAS No.: 1210049-13-0
• Molecular Formula: C₁₅H₁₁BrF₃NO
• Molecular Weight: 358.158
• Mol file: 1210049-13-0.mol

Synonyms:N-(1-(4-bromophenyl)-2,2,2-trifluoroethylidene)-4-methoxyaniline

Chemical Property of N-(1-(4-bromophenyl)-2,2,2-trifluoroethylidene)-4-methoxyaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-(4-bromophenyl)-2,2,2-trifluoroethylidene)-4-methoxyaniline

There total 1 articles about N-(1-(4-bromophenyl)-2,2,2-trifluoroethylidene)-4-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4'-bromo-2,2,2-trifluoroacetophenone (16184-89-7) + 4-methoxy-N-(triphenylphosphoran-ylidene)-aniline (14796-89-5) → N-(1-(4-bromophenyl)-2,2,2-trifluoroethylidene)-4-methoxyaniline (1210049-13-0)

Guidance literature:

In toluene; at 120 ℃; for 24h;

DOI:10.1002/anie.201103240

Reference yield: 99.0%

trimethylsilyl cyanide (7677-24-9) + N-(1-(4-bromophenyl)-2,2,2-trifluoroethylidene)-4-methoxyaniline (1210049-13-0) → (S)-2-(4-bromophenyl)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)propanenitrile (1263499-10-0)

Guidance literature:

With isopropyl alcohol; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In 1,2-dichloro-ethane; at 20 ℃; for 144h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/adsc.201000666

Reference yield: 95.0%

N-(1-(4-bromophenyl)-2,2,2-trifluoroethylidene)-4-methoxyaniline (1210049-13-0) → (R)-N-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-4-meth-oxyaniline

Guidance literature:

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; benzo[1,3,2]dioxaborole; In Cyclopentane; at 20 ℃; for 1h; enantioselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.joc.0c03009

upstream raw materials:

4'-bromo-2,2,2-trifluoroacetophenone

4-methoxy-N-(triphenylphosphoran-ylidene)-aniline

Downstream raw materials:

(S)-2-(4-bromophenyl)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)propanenitrile

2-(4-bromophenyl)-3,3,3-trifluoro-1-(furan-2-yl)-2-(4-methoxyphenylamino)propan-1-one

(S)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-4-methoxyaniline

(R)-2-(4-bromophenyl)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)propanenitrile