benzyl 3,3-difluoro-2-(4-methoxyphenyl)amino-2-(2-methylallyl)-5-hexenoate

Base Information

Chemical Name:benzyl 3,3-difluoro-2-(4-methoxyphenyl)amino-2-(2-methylallyl)-5-hexenoate
CAS No.:911395-39-6
Molecular Formula:C₂₄H₂₇F₂NO₃
Molecular Weight:415.48
Hs Code.:

Synonyms:benzyl 3,3-difluoro-2-(4-methoxyphenyl)amino-2-(2-methylallyl)-5-hexenoate

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Chemical Property of benzyl 3,3-difluoro-2-(4-methoxyphenyl)amino-2-(2-methylallyl)-5-hexenoate

Chemical Property:

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Technology Process of benzyl 3,3-difluoro-2-(4-methoxyphenyl)amino-2-(2-methylallyl)-5-hexenoate

There total 5 articles about benzyl 3,3-difluoro-2-(4-methoxyphenyl)amino-2-(2-methylallyl)-5-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1039136-70-3
benzyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate

: 1458-98-6
2-methyl-3-bromo-1-propene

: 911395-39-6
benzyl 3,3-difluoro-2-(4-methoxyphenyl)amino-2-(2-methylallyl)-5-hexenoate

Guidance literature:: 2-methyl-3-bromo-1-propene; With zinc; In tetrahydrofuran; at 50 ℃; for 0.666667h;

benzyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate; In tetrahydrofuran; at -40 ℃; for 0.166667h;
DOI:10.1021/ol061733c

Reference yield:

: 2,2-difluoro-N-(4-methoxy-phenyl)-pent-4-enimidoyl iodide

: 911395-39-6
benzyl 3,3-difluoro-2-(4-methoxyphenyl)amino-2-(2-methylallyl)-5-hexenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 60 percent / K₂CO₃; Pd₂(dba)3*CHCl₃ / toluene; dimethylformamide / 20 °C / 760 Torr

2.1: Zn / tetrahydrofuran / 0.67 h / 50 °C

2.2: 99 percent / tetrahydrofuran / 0.17 h / -40 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium carbonate; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol061733c

Reference yield:

: 55039-89-9
2,2-difluoropent-4-enoic acid

: 911395-39-6
benzyl 3,3-difluoro-2-(4-methoxyphenyl)amino-2-(2-methylallyl)-5-hexenoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Ph₃P; Et₃N; CCl₄ / 3 h / Heating

2.1: NaI / acetone / 20 °C

3.1: 60 percent / K₂CO₃; Pd₂(dba)3*CHCl₃ / toluene; dimethylformamide / 20 °C / 760 Torr

4.1: Zn / tetrahydrofuran / 0.67 h / 50 °C

4.2: 99 percent / tetrahydrofuran / 0.17 h / -40 °C

With tetrachloromethane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium carbonate; triethylamine; triphenylphosphine; sodium iodide; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ol061733c