(2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1-phosphonooxymethyl-1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Base Information

Chemical Name:(2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1-phosphonooxymethyl-1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester
CAS No.:1394049-77-4
Molecular Formula:C₂₈H₃₁N₄O₁₁P
Molecular Weight:630.548
Hs Code.:

(2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1-phosphonooxymethyl-1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Synonyms:(2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1-phosphonooxymethyl-1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

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Chemical Property of (2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1-phosphonooxymethyl-1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

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Technology Process of (2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1-phosphonooxymethyl-1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

There total 4 articles about (2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1-phosphonooxymethyl-1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394049-42-3
(2S,4R)-5-(biphenyl-4-yl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyl ester

: 229625-50-7
di-tert-butyl chloromethyl phosphate

: 1394049-77-4
(2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1-phosphonooxymethyl-1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

: 1394050-68-0
(2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3-phosphonooxymethyl-3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Guidance literature:: (2S,4R)-5-(biphenyl-4-yl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyl ester; di-tert-butyl chloromethyl phosphate; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; ethyl acetate; N,N-dimethyl-formamide; pH=4 - 5;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.333333h;

Reference yield:

: 1394050-43-1
(2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)methyl ester

: 1394049-77-4
(2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1-phosphonooxymethyl-1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

: 1394050-68-0
(2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3-phosphonooxymethyl-3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 18 h / 0 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere; Industry scale

2.2: 0.5 h / 0 °C / Inert atmosphere

3.1: hydrogenchloride; methanol / 2 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.2: pH 4 - 5

4.3: 0.33 h / 20 °C

With hydrogenchloride; methanol; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); potassium carbonate; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1394050-32-8
(2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[((1-trityl)-1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)methyl ester

: 1394049-77-4
(2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1-phosphonooxymethyl-1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

: 1394050-68-0
(2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3-phosphonooxymethyl-3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; methanol / 2 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: pH 4 - 5

2.3: 0.33 h / 20 °C

With hydrogenchloride; methanol; potassium carbonate; In N,N-dimethyl-formamide;