racemic 3-cyclohexyl-2-methylpropanoic acid

Base Information

• Chemical Name: racemic 3-cyclohexyl-2-methylpropanoic acid
• CAS No.: 51953-02-7
• Molecular Formula: C₁₀H₁₈O₂
• Molecular Weight: 170.252
• Mol file: 51953-02-7.mol

Synonyms:racemic 3-cyclohexyl-2-methylpropanoic acid

Chemical Property of racemic 3-cyclohexyl-2-methylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of racemic 3-cyclohexyl-2-methylpropanoic acid

There total 9 articles about racemic 3-cyclohexyl-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-methyl-3-phenylpropanoic acid (1009-67-2) → racemic 3-cyclohexyl-2-methylpropanoic acid (51953-02-7)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; for 4h; under 38000 Torr; Ambient temperature;

DOI:10.1248/cpb.35.2426

Reference yield:

2-Cyclohexylmethyl-2-methyl-malonic acid → racemic 3-cyclohexyl-2-methylpropanoic acid (51953-02-7)

Guidance literature:

at 270 ℃;

DOI:10.1016/0223-5234(96)88235-3

Reference yield:

3-cyclohexylpropan-1-ol (1124-63-6) → racemic 3-cyclohexyl-2-methylpropanoic acid (51953-02-7)

Guidance literature:

With water; tetracarbonyl nickel; nickel dichloride; at 300 ℃; under 29420.3 Torr; weiteres Reagens: wss. HCl;

DOI:10.1021/ja01166a060

upstream raw materials:

2-methyl-3-phenylpropanoic acid

3-cyclohexylpropan-1-ol

diethyl 2-(cyclohexylmethyl)-2-methylmalonate

Cyclohexylmethyl bromide

Downstream raw materials:

2-methyl-3-cyclohexylpropionyl chloride

2-methyl-3-cyclohexylpropanol

Refernces

• 1、 Li, Daxiong,Zhang, Chunsheng,Ding, Wei,Huang, Siming,Yu, Le,Lu, Nan,Pan, Wenkai,Li, Yiming,De Clercq, Erik,Pannecouque, Christophe,Zhang, Hongbing,Wang, Yueping,He, Yanping,Chen, Fener. "Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors". supporting information. p. 1020 - 1024. Retrieved 2020/10/12.
• 2、 Nordin, Ove,Nguyen, Ba-Vu,Voerde, Carin,Hedenstroem, Erik,Hoegberg, Hans-Erik. "Kinetic resolution of primary 2-methyl-substituted alcohols via Pseudomonas cepacia lipase-catalysed enantioselective acylation". . p. 367 - 376. Retrieved 2007/10/03.