(S)-methyl (3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylcarbamate

Base Information

Chemical Name:(S)-methyl (3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylcarbamate
CAS No.:1430321-56-4
Molecular Formula:C₁₈H₂₅F₂N₃O₄Si
Molecular Weight:413.497
Hs Code.:

Synonyms:(S)-methyl (3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylcarbamate

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Chemical Property of (S)-methyl (3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylcarbamate

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Technology Process of (S)-methyl (3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylcarbamate

There total 12 articles about (S)-methyl (3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 67-56-1
methanol

: 1430321-53-1
(S)-5-(aminomethyl)-3-(4-(4,4-diniethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)oxazolidin-2-one

: 530-62-1
1,1'-carbonyldiimidazole

: 1430321-56-4
(S)-methyl (3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylcarbamate

Guidance literature:: (S)-5-(aminomethyl)-3-(4-(4,4-diniethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)oxazolidin-2-one; 1,1'-carbonyldiimidazole; With triethylamine; In dichloromethane; at 25 ℃; for 4h;

methanol; In dichloromethane; at 25 ℃; for 24h;

Reference yield:

: 67-56-1
methanol

: C₂₀H₂₅F₂N₅O₃Si

: 1430321-56-4
(S)-methyl (3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylcarbamate

Guidance literature:: In dichloromethane; at 25 ℃; for 24h;

Reference yield:

: 1430321-66-6
1-(2,6-difluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

: 1430321-56-4
(S)-methyl (3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 1810.07 Torr

2: sodium hydrogencarbonate / tetrahydrofuran / 5 h / 25 °C

3: lithium tert-butoxide / N,N-dimethyl-formamide / 45 h / 0 - 25 °C

4: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

5: triethylamine / dichloromethane / 4 h / 25 °C

6: dichloromethane / 24 h / 25 °C

With palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; lithium tert-butoxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;