4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-1-(4-hydroxybutanoyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one

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Chemical Name:4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-1-(4-hydroxybutanoyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one
CAS No.:1449374-39-3
Molecular Formula:C₂₈H₂₃Cl₂N₃O₃
Molecular Weight:520.415
Hs Code.:

Synonyms:4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-1-(4-hydroxybutanoyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one

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Chemical Property of 4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-1-(4-hydroxybutanoyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one

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Technology Process of 4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-1-(4-hydroxybutanoyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one

There total 7 articles about 4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-1-(4-hydroxybutanoyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1449373-99-2
4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobutanoic acid

: 1449374-39-3
4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-1-(4-hydroxybutanoyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 2894-51-1
2-amino-4'-chlorobenzophenone

: 1449374-39-3
4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-1-(4-hydroxybutanoyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 0.5 h / 160 °C / Microwave irradiation; Molecular sieve

2.1: potassium hydroxide / water; ethanol / 0.75 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrazine / ethanol / 0.33 h / 110 °C / Microwave irradiation

4.1: tetrahydrofuran / 0.33 h / 165 °C / Microwave irradiation; Molecular sieve

5.1: dimethylsulfide borane complex / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

With dimethylsulfide borane complex; potassium hydroxide; hydrazine; In tetrahydrofuran; ethanol; hexane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400652r

Reference yield:

: 1449373-56-1
4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one

: 1449374-39-3
4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-1-(4-hydroxybutanoyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.33 h / 165 °C / Microwave irradiation; Molecular sieve

2: dimethylsulfide borane complex / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

With dimethylsulfide borane complex; In tetrahydrofuran; hexane;
DOI:10.1021/jm400652r