N-(1-cyclohexyl-5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-amine

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Chemical Name:N-(1-cyclohexyl-5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-amine
CAS No.:1012104-52-7
Molecular Formula:C₃₇H₄₉N₇O₃Si
Molecular Weight:667.927
Hs Code.:

Synonyms:N-(1-cyclohexyl-5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-amine

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Chemical Property of N-(1-cyclohexyl-5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-amine

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Technology Process of N-(1-cyclohexyl-5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-amine

There total 13 articles about N-(1-cyclohexyl-5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1012104-51-6
1-cyclohexyl-2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1H-benzo[d]imidazole-5-carbaldehyde

: 1012104-52-7
N-(1-cyclohexyl-5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-amine

Guidance literature:: morpholine; 1-cyclohexyl-2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1H-benzo[d]imidazole-5-carbaldehyde; With acetic acid; In dichloromethane; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

: 53857-57-1
5-bromo-1H-indazole

: 1012104-52-7
N-(1-cyclohexyl-5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0 °C

2.2: 0 - 20 °C

3.1: potassium phosphate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / 5 h / 140 °C / Inert atmosphere; Microwave irradiation

4.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.35 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: Dess-Martin periodane / 1 h / 0 °C / Cooling with ice

6.1: acetic acid / dichloromethane / 0.17 h / 20 °C

6.2: 20 °C

With potassium phosphate; iodine; sodium hydride; sodium carbonate; Dess-Martin periodane; acetic acid; potassium hydroxide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 347174-05-4
3-Amino-4-cyclohexylamino benzoic acid ethyl ester

: 1012104-52-7
N-(1-cyclohexyl-5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile; ethanol; water / 3.75 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere

3.1: potassium phosphate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / 5 h / 140 °C / Inert atmosphere; Microwave irradiation

4.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.35 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: Dess-Martin periodane / 1 h / 0 °C / Cooling with ice

6.1: acetic acid / dichloromethane / 0.17 h / 20 °C

6.2: 20 °C

With potassium phosphate; lithium aluminium tetrahydride; sodium carbonate; Dess-Martin periodane; acetic acid; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;