Multi-step reaction with 7 steps
1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0 °C
2.2: 0 - 20 °C
3.1: potassium phosphate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / 5 h / 140 °C / Inert atmosphere; Microwave irradiation
4.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 0.35 h / 120 °C / Inert atmosphere; Microwave irradiation
5.1: Dess-Martin periodane / 1 h / 0 °C / Cooling with ice
6.1: acetic acid / dichloromethane / 0.17 h / 20 °C
6.2: 20 °C
7.1: hydrogenchloride / ethanol / 2 h / 78 °C / Sealed vessel
With
hydrogenchloride; potassium phosphate; iodine; sodium hydride; sodium carbonate; Dess-Martin periodane; acetic acid; potassium hydroxide;
trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;