(1'R,2R,2'S,6R)-methanesulfonic acid 4-[benzyl-({6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-acetyl)-amino]-butyl ester

Base Information

Chemical Name:(1'R,2R,2'S,6R)-methanesulfonic acid 4-[benzyl-({6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-acetyl)-amino]-butyl ester
CAS No.:264218-73-7
Molecular Formula:C₄₃H₆₁N₃O₈S₂
Molecular Weight:812.105
Hs Code.:

(1'R,2R,2'S,6R)-methanesulfonic acid 4-[benzyl-({6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-acetyl)-amino]-butyl ester

Synonyms:(1'R,2R,2'S,6R)-methanesulfonic acid 4-[benzyl-({6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-acetyl)-amino]-butyl ester

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Chemical Property of (1'R,2R,2'S,6R)-methanesulfonic acid 4-[benzyl-({6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-acetyl)-amino]-butyl ester

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Technology Process of (1'R,2R,2'S,6R)-methanesulfonic acid 4-[benzyl-({6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-acetyl)-amino]-butyl ester

There total 10 articles about (1'R,2R,2'S,6R)-methanesulfonic acid 4-[benzyl-({6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-acetyl)-amino]-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 124-63-0
methanesulfonyl chloride

: 264218-71-5
(1'R,2R,2'S,6R)-N-benzyl-2-{6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-N-(4-hydroxy-butyl)-acetamide

: 264218-73-7
(1'R,2R,2'S,6R)-methanesulfonic acid 4-[benzyl-({6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-acetyl)-amino]-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at -20 ℃; for 0.5h;
DOI:10.1021/jo049724+

Reference yield:

: [(1R,5R,8aS)-1-((S)-1-Benzyloxy-hexyl)-3,7-dioxo-8-phenylselanyl-hexahydro-oxazolo[3,4-a]pyridin-5-yl]-acetic acid methyl ester

: 264218-73-7
(1'R,2R,2'S,6R)-methanesulfonic acid 4-[benzyl-({6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-acetyl)-amino]-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 65 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 0.25 h

2: 91 percent / 4-dimethylaminopyridine / toluene / 3 h / Heating

3: 91 percent / AIBN; (n-Bu)3SnH / toluene / 0.08 h / Heating

4: KOH / methanol; H₂O / 2 h / 20 °C

5: oxalyl chloride; N,N-dimethylformamide / CH₂Cl₂ / 1 h

6: 82 percent / NaOH / CH₂Cl₂ / 1.5 h

7: 88 percent / KOH / methanol; H₂O / 18 h / Heating

8: 84 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 3 h

9: 95 percent / Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

With dmap; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; cerium(III) chloride; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; water; toluene; 1: Luche reduction;
DOI:10.1021/jo049724+

Reference yield:

: 264218-65-7
(1R,1'S,5R,8aR)-N-benzyl-2-[3-oxo-1-((1'-phenylmethoxy)hexane)-1,5,6,8a-tetrahydro-oxazolo[3,4-a]pyridin-5-yl]-N-4-hydroxy-butyl acetamide

: 264218-73-7
(1'R,2R,2'S,6R)-methanesulfonic acid 4-[benzyl-({6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-acetyl)-amino]-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / KOH / methanol; H₂O / 18 h / Heating

2: 84 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 3 h

3: 95 percent / Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

With potassium hydroxide; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water;
DOI:10.1021/jo049724+