3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-benzonitrile

Base Information

Chemical Name:3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-benzonitrile
CAS No.:1357262-69-1
Molecular Formula:C₂₉H₂₃N₅
Molecular Weight:441.535
Hs Code.:

Synonyms:3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-benzonitrile

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Chemical Property of 3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-benzonitrile

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Technology Process of 3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-benzonitrile

There total 5 articles about 3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357263-12-7
(1-{4-[3-(3-cyanophenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}cyclobutyl)-carbamic acid tert.-butyl ester

: 1357262-69-1
3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-benzonitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 120h;

Reference yield:

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1357262-69-1
3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 24 h / 90 °C / Microwave irradiation; Inert atmosphere

2: N-Bromosuccinimide / chloroform / 1 h / Reflux

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 1.67 h / 100 °C / Microwave irradiation

4: hydrogenchloride / 1,4-dioxane / 120 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; chloroform;

Reference yield:

: 1357263-07-0
{1-[4-(7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1357262-69-1
3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / chloroform / 1 h / Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 1.67 h / 100 °C / Microwave irradiation

3: hydrogenchloride / 1,4-dioxane / 120 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; In tetrahydrofuran; 1,4-dioxane; chloroform;