Boc-Ser(Trt)-N-methoxy-N-methyl amide

Base Information

• Chemical Name: Boc-Ser(Trt)-N-methoxy-N-methyl amide
• CAS No.: 252897-68-0
• Molecular Formula: C₂₉H₃₄N₂O₅
• Molecular Weight: 490.599
• Mol file: 252897-68-0.mol

Synonyms:Boc-Ser(Trt)-N-methoxy-N-methyl amide

Chemical Property of Boc-Ser(Trt)-N-methoxy-N-methyl amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Ser(Trt)-N-methoxy-N-methyl amide

There total 2 articles about Boc-Ser(Trt)-N-methoxy-N-methyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → Boc-Ser(Trt)-N-methoxy-N-methyl amide (252897-68-0)

Guidance literature:

Boc-Ser(Trt)-OH; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

N,O-dimethylhydroxylamine*hydrochloride; In dichloromethane; for 0.333333h;

Reference yield: 98.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + Boc-Ser(Trt)-OH (252897-67-9) → Boc-Ser(Trt)-N-methoxy-N-methyl amide (252897-68-0)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.333333h;

DOI:10.1016/S0040-4039(99)01654-8

Reference yield: 94.0%

Boc-Ser(Trt)-N-methoxy-N-methyl amide (252897-68-0) → Nα-Boc-O-trityl-L-serinal (252897-69-1)

Guidance literature:

Boc-Ser(Trt)-N-methoxy-N-methyl amide; With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 0.5h;

With potassium hydrogensulfate; water; In diethyl ether; for 0.25h;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

Boc-Ser(Trt)-OH

Downstream raw materials:

Nα-Boc-O-trityl-L-serinal

2-((S)-1-Amino-2-trityloxy-ethyl)-thiazole-4-carboxylic acid methyl ester

2-(1-tert-butoxycarbonylamino-2-trityloxy-ethyl)-thiazole-4-carboxylic acid methyl ester

(R)-2-((S)-1-tert-Butoxycarbonylamino-2-trityloxy-ethyl)-thiazolidine-4-carboxylic acid methyl ester