Technology Process of N1-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenyl)-N8-hydroxyoctanediamide
There total 8 articles about N1-(4-(1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenyl)-N8-hydroxyoctanediamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydroxylamine;
potassium cyanide;
In
tetrahydrofuran; methanol; water;
at 35 - 40 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Cooling with ice
1.2: 1.17 h / 20 - 120 °C
2.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Cooling with ice
4.1: trifluoroacetic acid / dichloromethane / 19 h / 20 °C
5.1: oxalyl dichloride / N,N-dimethyl-formamide / 0.5 h / -30 - -15 °C
6.1: pyridine / 0.5 h / -60 - -20 °C
7.1: hydroxylamine / potassium cyanide / tetrahydrofuran; methanol; water / 24 h / 35 - 40 °C
With
pyridine; oxalyl dichloride; potassium tert-butylate; hydroxylamine; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
potassium cyanide; palladium 10% on activated carbon; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Cooling with ice
3: trifluoroacetic acid / dichloromethane / 19 h / 20 °C
4: oxalyl dichloride / N,N-dimethyl-formamide / 0.5 h / -30 - -15 °C
5: pyridine / 0.5 h / -60 - -20 °C
6: hydroxylamine / potassium cyanide / tetrahydrofuran; methanol; water / 24 h / 35 - 40 °C
With
pyridine; oxalyl dichloride; hydroxylamine; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
potassium cyanide; palladium 10% on activated carbon; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
