3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

Base Information

• Chemical Name: 3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile
• CAS No.: 1432048-72-0
• Molecular Formula: C₁₂H₈F₃NO₂
• Molecular Weight: 255.196
• Mol file: 1432048-72-0.mol

Synonyms:3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

Chemical Property of 3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

There total 2 articles about 3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-hydroxy-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile (1432048-71-9) + Dess-Martin periodane (87413-09-0) → 3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile (1432048-72-0)

Guidance literature:

In dichloromethane; at 20 ℃;

Reference yield:

(4-trifluoromethoxy-phenyl)-acetonitrile (49561-96-8) → 3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile (1432048-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethyl ether; tetrahydrofuran / 1 h / -75 °C

1.2: 1 h / -75 °C

1.3: 20 °C

2.1: Dess-Martin periodane / dichloromethane / 20 °C

With Dess-Martin periodane; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield: 84.0%

3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile (1432048-72-0) → 3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile (1432048-73-1)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃; for 48h;

upstream raw materials:

(4-trifluoromethoxy-phenyl)-acetonitrile

3-hydroxy-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

Dess-Martin periodane

Downstream raw materials:

(S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl} (pyridin-2-yl)-methanol

3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)methanone

(S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)-methanol hydrochloride