(S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)-methanol hydrochloride

Base Information

• Chemical Name: (S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)-methanol hydrochloride
• CAS No.: 1432048-70-8
• Molecular Formula: C₁₇H₁₄F₅NO₂*ClH
• Molecular Weight: 395.757
• Mol file: 1432048-70-8.mol

Synonyms:(S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)-methanol hydrochloride

Chemical Property of (S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)-methanol hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)-methanol hydrochloride

There total 6 articles about (S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)-methanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl} (pyridin-2-yl)-methanol (1432097-48-7) → (S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)-methanol hydrochloride (1432048-70-8)

Guidance literature:

With hydrogenchloride; In methanol;

Reference yield:

{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)methanone (1432048-74-2) → (S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)-methanol hydrochloride (1432048-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid; triethylamine; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II) / 35 °C

2: hydrogenchloride / methanol

With hydrogenchloride; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); formic acid; triethylamine; In methanol;

Reference yield:

3-hydroxy-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile (1432048-71-9) → (S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl}(pyridin-2-yl)-methanol hydrochloride (1432048-70-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Dess-Martin periodane / dichloromethane / 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 48 h / 0 - 20 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.67 h / -70 °C

3.2: 3 h / 0 °C

4.1: formic acid; triethylamine; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II) / 35 °C

5.1: hydrogenchloride / methanol

With hydrogenchloride; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); n-butyllithium; formic acid; diethylamino-sulfur trifluoride; Dess-Martin periodane; triethylamine; In methanol; diethyl ether; hexane; dichloromethane;

upstream raw materials:

(S)-{3,3-difluoro-1-[4-(trifluoromethoxy)phenyl]cyclobutyl} (pyridin-2-yl)-methanol

3-hydroxy-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

(4-trifluoromethoxy-phenyl)-acetonitrile

3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile