tert-butyl 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl oxalate

Base Information

• Chemical Name: tert-butyl 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl oxalate
• CAS No.: 1349255-26-0
• Molecular Formula: C₂₉H₂₉ClN₂O₇S
• Molecular Weight: 585.077
• Mol file: 1349255-26-0.mol

Synonyms:tert-butyl 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl oxalate

Chemical Property of tert-butyl 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl oxalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl oxalate

There total 4 articles about tert-butyl 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

t-butoxalyl chloride (39061-59-1) + C23H21ClN2O4S (1026063-71-7) → tert-butyl 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl oxalate (1349255-26-0)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/jm500026w

Reference yield:

potassium 2-methoxy-4-nitrophenolate monohydrate (100200-99-5) → tert-butyl 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl oxalate (1349255-26-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium dihydrogenphosphate / water; acetonitrile / 3 h / 170 °C / 155149 Torr / Autoclave; Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr / Inert atmosphere

3: ethanol / 15 h / Reflux; Inert atmosphere

4: pyridine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With pyridine; sodium dihydrogenphosphate; palladium 10% on activated carbon; hydrogen; In ethanol; dichloromethane; water; acetonitrile;

DOI:10.1021/jm500026w

Reference yield:

1-(2-methoxy-4-nitrophenoxy)-2-methylpropan-2-ol (945720-36-5) → tert-butyl 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl oxalate (1349255-26-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr / Inert atmosphere

2: ethanol / 15 h / Reflux; Inert atmosphere

3: pyridine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; In ethanol; dichloromethane;

DOI:10.1021/jm500026w

upstream raw materials:

potassium 2-methoxy-4-nitrophenolate monohydrate

1-(2-methoxy-4-nitrophenoxy)-2-methylpropan-2-ol

1-(2-methoxy-4-aminophenoxy)-2-methylpropan-2-ol

t-butoxalyl chloride