N-cyclohexyl 2-{N-(3-phenylpropiolyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-(p-chlorophenyl)acetamide

Base Information

Chemical Name:N-cyclohexyl 2-{N-(3-phenylpropiolyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-(p-chlorophenyl)acetamide
CAS No.:1366088-56-3
Molecular Formula:C₄₆H₃₈ClF₃N₄O₄
Molecular Weight:803.28
Hs Code.:

N-cyclohexyl 2-{N-(3-phenylpropiolyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-(p-chlorophenyl)acetamide

Synonyms:N-cyclohexyl 2-{N-(3-phenylpropiolyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-(p-chlorophenyl)acetamide

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Chemical Property of N-cyclohexyl 2-{N-(3-phenylpropiolyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-(p-chlorophenyl)acetamide

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Technology Process of N-cyclohexyl 2-{N-(3-phenylpropiolyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-(p-chlorophenyl)acetamide

There total 6 articles about N-cyclohexyl 2-{N-(3-phenylpropiolyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-(p-chlorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 931-53-3
Cyclohexyl isocyanide

: 1366088-23-4
3-benzyl-5-(m-aminophenyl)-1-(m-trifluoromethylphenyl)imidazolidine-2,4-dione

: 104-88-1
4-chlorobenzaldehyde

: 637-44-5
phenylpropyolic acid

: 1366088-56-3
N-cyclohexyl 2-{N-(3-phenylpropiolyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-(p-chlorophenyl)acetamide

Guidance literature:: 3-benzyl-5-(m-aminophenyl)-1-(m-trifluoromethylphenyl)imidazolidine-2,4-dione; 4-chlorobenzaldehyde; In methanol; for 0.5h; Reflux;

Cyclohexyl isocyanide; phenylpropyolic acid; In methanol; Reflux;
DOI:10.1016/j.tet.2012.01.073

Reference yield:

: 1366087-99-1
N-benzyl-2-[N-(3-trifluoromethylphenyl)-N-(trichloroacetyl)amino]-2-(m-nitrophenyl)acetamide

: 1366088-56-3
N-cyclohexyl 2-{N-(3-phenylpropiolyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-(p-chlorophenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / methanol / 0.08 h

2.1: iron; acetic acid / 0.5 h / 50 - 60 °C

3.1: methanol / 0.5 h / Reflux

3.2: Reflux

With sodium ethanolate; iron; acetic acid; In methanol; 3.1: Ugi condensation / 3.2: Ugi condensation;
DOI:10.1016/j.tet.2012.01.073

Reference yield:

: 1366088-11-0
3-benzyl-5-(m-nitrophenyl)-1-(m-trifluoromethylphenyl)imidazolidine-2,4-dione

: 1366088-56-3
N-cyclohexyl 2-{N-(3-phenylpropiolyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-(p-chlorophenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: iron; acetic acid / 0.5 h / 50 - 60 °C

2.1: methanol / 0.5 h / Reflux

2.2: Reflux

With iron; acetic acid; In methanol; 2.1: Ugi condensation / 2.2: Ugi condensation;
DOI:10.1016/j.tet.2012.01.073