N-benzyl-2-[N-(3-trifluoromethylphenyl)-N-(trichloroacetyl)amino]-2-(m-nitrophenyl)acetamide

Base Information

Chemical Name:N-benzyl-2-[N-(3-trifluoromethylphenyl)-N-(trichloroacetyl)amino]-2-(m-nitrophenyl)acetamide
CAS No.:1366087-99-1
Molecular Formula:C₂₄H₁₇Cl₃F₃N₃O₄
Molecular Weight:574.771
Hs Code.:

Synonyms:N-benzyl-2-[N-(3-trifluoromethylphenyl)-N-(trichloroacetyl)amino]-2-(m-nitrophenyl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzyl-2-[N-(3-trifluoromethylphenyl)-N-(trichloroacetyl)amino]-2-(m-nitrophenyl)acetamide

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Technology Process of N-benzyl-2-[N-(3-trifluoromethylphenyl)-N-(trichloroacetyl)amino]-2-(m-nitrophenyl)acetamide

There total 1 articles about N-benzyl-2-[N-(3-trifluoromethylphenyl)-N-(trichloroacetyl)amino]-2-(m-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 88333-03-3,10340-91-7
Benzyl isocyanide

: 99-61-6
3-nitro-benzaldehyde

: 98-16-8
3-trifluoromethylaniline

: 76-03-9
trichloroacetic acid

: 1366087-99-1
N-benzyl-2-[N-(3-trifluoromethylphenyl)-N-(trichloroacetyl)amino]-2-(m-nitrophenyl)acetamide

Guidance literature:: 3-nitro-benzaldehyde; 3-trifluoromethylaniline; In methanol; at 20 ℃; for 0.166667h;

Benzyl isocyanide; trichloroacetic acid; In methanol; at 20 ℃; for 24h;
DOI:10.1016/j.tet.2012.01.073

Reference yield: 95.0%

: 1366087-99-1
N-benzyl-2-[N-(3-trifluoromethylphenyl)-N-(trichloroacetyl)amino]-2-(m-nitrophenyl)acetamide

: 1366088-11-0
3-benzyl-5-(m-nitrophenyl)-1-(m-trifluoromethylphenyl)imidazolidine-2,4-dione

Guidance literature:: With sodium ethanolate; In methanol; for 0.0833333h;
DOI:10.1016/j.tet.2012.01.073

Reference yield:

: 1366087-99-1
N-benzyl-2-[N-(3-trifluoromethylphenyl)-N-(trichloroacetyl)amino]-2-(m-nitrophenyl)acetamide

: 1366088-50-7
N-cyclohexyl 2-{N-(p-chlorophenoxyacetyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-(p-tolyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / methanol / 0.08 h

2.1: iron; acetic acid / 0.5 h / 50 - 60 °C

3.1: methanol / 0.5 h / Reflux

3.2: Reflux

With sodium ethanolate; iron; acetic acid; In methanol; 3.1: Ugi condensation / 3.2: Ugi condensation;
DOI:10.1016/j.tet.2012.01.073