Technology Process of (E)-ethyl 1-(4-(7-(1,3-dioxolan-2-yl)hept-2-enyloxy)phenyl)hydrazinecarboxylate
There total 7 articles about (E)-ethyl 1-(4-(7-(1,3-dioxolan-2-yl)hept-2-enyloxy)phenyl)hydrazinecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; 1,10-Phenanthroline; caesium carbonate;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 3h;
Inert atmosphere;
DOI:10.1002/anie.201108970
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: HMPA / 0.5 h / Inert atmosphere
1.3: 5 h / Inert atmosphere
2.1: trifluoroacetic acid / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 0 - 20 °C / Inert atmosphere
4.1: phosphorus tribromide / dichloromethane / 3 h / 0 °C / Inert atmosphere
5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
5.2: 6 h / Inert atmosphere; Reflux
6.1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere
With
copper(l) iodide; n-butyllithium; 1,10-Phenanthroline; phosphorus tribromide; potassium carbonate; caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201108970
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trifluoroacetic acid / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 0 - 20 °C / Inert atmosphere
3.1: phosphorus tribromide / dichloromethane / 3 h / 0 °C / Inert atmosphere
4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
4.2: 6 h / Inert atmosphere; Reflux
5.1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere
With
copper(l) iodide; 1,10-Phenanthroline; phosphorus tribromide; potassium carbonate; caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201108970
