Technology Process of (E)-2-(7-(4-iodophenoxy)hept-5-enyl)-1,3-dioxolane
There total 4 articles about (E)-2-(7-(4-iodophenoxy)hept-5-enyl)-1,3-dioxolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
p-Iodophenol; C8H15BrO2; C10H17BrO2;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
Inert atmosphere;
ethylene glycol;
With
toluene-4-sulfonic acid;
In
benzene;
for 6h;
Inert atmosphere;
Reflux;
DOI:10.1002/anie.201108970
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: HMPA / 0.5 h / Inert atmosphere
1.3: 5 h / Inert atmosphere
2.1: trifluoroacetic acid / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 0 - 20 °C / Inert atmosphere
4.1: phosphorus tribromide / dichloromethane / 3 h / 0 °C / Inert atmosphere
5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
5.2: 6 h / Inert atmosphere; Reflux
With
n-butyllithium; phosphorus tribromide; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201108970
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 0 - 20 °C / Inert atmosphere
2.1: phosphorus tribromide / dichloromethane / 3 h / 0 °C / Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
3.2: 6 h / Inert atmosphere; Reflux
With
phosphorus tribromide; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201108970
