(1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarboxylic acid

Base Information

Chemical Name:(1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarboxylic acid
CAS No.:1369768-95-5
Molecular Formula:C₁₆H₁₄ClFN₂O₃
Molecular Weight:336.75
Hs Code.:

Synonyms:(1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarboxylic acid

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Chemical Property of (1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarboxylic acid

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Technology Process of (1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarboxylic acid

There total 5 articles about (1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369768-94-4
(1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde

: 1369768-95-5
(1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; acetone; at 35 ℃; for 18h; Cooling with ice;

Reference yield:

: 1369768-93-3
{(1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropyl}methanol

: 1369768-95-5
(1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

1.2: 2 h / -78 - 0 °C

2.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; acetone / 18 h / 35 °C / Cooling with ice

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; water; acetone; 1.1: Swern Oxidation;

Reference yield:

: 1245506-62-0
2-chloro-4-methylpyrimidin-5-ol

: 1369768-95-5
(1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 14 h / 35 °C / Cooling with ice

2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 10 - 35 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

3.2: 2 h / -78 - 0 °C

4.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; acetone / 18 h / 35 °C / Cooling with ice

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; di-isopropyl azodicarboxylate; water; dimethyl sulfoxide; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; 1.1: Mitsunobu reaction / 3.1: Swern Oxidation;