ethyl (2S)-1-[(1S,2R)-2-hydroxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate

Base Information

• Chemical Name: ethyl (2S)-1-[(1S,2R)-2-hydroxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate
• CAS No.: 1263054-42-7
• Molecular Formula: C₃₅H₃₈N₂O₅S
• Molecular Weight: 598.763

Synonyms:ethyl (2S)-1-[(1S,2R)-2-hydroxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate

Chemical Property of ethyl (2S)-1-[(1S,2R)-2-hydroxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate

Chemical Property:

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Technology Process of ethyl (2S)-1-[(1S,2R)-2-hydroxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate

There total 1 articles about ethyl (2S)-1-[(1S,2R)-2-hydroxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-isopropyl-4-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid ethyl ester (461641-24-7) → ethyl (2S)-1-[(1S,2R)-2-hydroxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate (1263054-42-7)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1039/c0ob00627k

Reference yield: 34.0%

ethyl (2S)-1-[(1S,2R)-2-hydroxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate (1263054-42-7) + tert-butyldimethylsilyl chloride (18162-48-6) → ethyl (2S)-1-[(1S,2R)-cis-2-tert-butyldimethylsilyloxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate (1263054-45-0)

Guidance literature:

With dmap; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 20h;

DOI:10.1039/c0ob00627k

Reference yield:

ethyl (2S)-1-[(1S,2R)-2-hydroxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate (1263054-42-7) + ethylmagnesium bromide (925-90-6) → C37H44N2O5S (1263054-43-8) + ethyl (2S,3S)-3-ethyl-1-[(1S,2R)-2-hydroxy-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)piperidine-4-carboxylate

Guidance literature:

In diethyl ether; at 0 ℃; optical yield given as %de;

DOI:10.1039/c0ob00627k

upstream raw materials:

5-isopropyl-4-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid ethyl ester

Downstream raw materials:

C₃₇H₄₄N₂O₅S

ethyl (2S)-1-[(1S,2R)-cis-2-tert-butyldimethylsilyloxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate

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