461641-24-7

Upstream product

• 1669-43-8 (E)-4-isopropylbut-3-en-2-one 
• 765914-04-3 3-ethynyl-1-(toluene-4-sulfonyl)-1H-indole 
• 461640-89-1 C₂₉H₄₁NO₂SSn 
• 461640-97-1 (1S,2R)-(-)-cis-1-amino-7-isopropylindan-2-ol 
• 848760-13-4 5-p-toluenesulfonyloxy-7-isopropyl-1-indanone 
• 676121-65-6 5-hydroxy-7-isopropyl-1-indanone 
• 676121-64-5 7-isopropyl-hexahydro-indene-1,5-dione 
• 676121-66-7 7-isopropylindan-1-ol 
• 152685-98-8 4-isopropyl-1-indene 
• 461641-21-4 (E)-4-Hydroxy-2-{(E)-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-vinyl}-but-2-enoic acid ethyl ester 
• 461640-90-4 ethyl (Z)-4-hydroxy-2-iodo-2-butenoate 
• 676121-63-4 5-methyl-2-trimethylsilyloxy-1,3(E)-hexadiene 
• 65651-63-0 4-hydroxy-5-methyl-hexan-2-one 
• 50562-79-3 1-(4-tolylsulfonyl)indole-3-carboxaldehyde 

Downstream Products

• 461641-26-9 (2S)-(-)-4-hydroxymethyl-N-methyl-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine 
• 461641-27-0 (2S)-(-)-4-(1-hydroxyethyl)-N-methyl-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine 
• 1263054-42-7 ethyl (2S)-1-[(1S,2R)-2-hydroxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate 
• 461640-92-6 (2S)-(-)-4-hydroxymethyl-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine 
• 461641-25-8 1-{4-hydroxymethyl-6-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3,6-dihydro-2H-pyridin-1-yl}-7-isopropyl-indan-2-ol 

Relevant academic research and scientific papers

Stereocontrolled synthesis of substituted chiral piperidines viaone-pot asymmetric 6π-azaelectrocyclization: Asymmetric syntheses of(-)-dendroprimine, (+)-7-epidendroprimine, (+)-5-epidendroprimine, and (+)-5,7-epidendroprimine

The asymmetric one-pot 6π-azaelectrocyclization of alkenyl vinyl stannane, ethyl (Z)-2-iodo-4-oxobutenoate, and (-)-7-isopropyl-cis-aminoindanol in the presence of a Pd(0) catalyst stereoselectively produced the tetracyclic aminoacetal compounds, resultin

Total synthesis of (-)-20-epiuleine via stereocontrolled one-pot asymmetric azaelectrocyclization followed by novel 1,4-addition reaction

The first asymmetric total synthesis of an indole alkaloid, (-)-20-epiuleine, containing the 2,3,4-trisubstituted piperidine core, was achieved using a stereocontrolled one-pot asymmetric 6π-azaelectrocyclization followed by a stereoselective 1,4-addition

Development of a one-pot asymmetric azaelectrocyclization protocol: Synthesis of chiral 2,4-disubstituted 1,2,5,6-tetrahydropyridines

A one-pot procedure for tetracyclic chiral aminoacetals, the useful precursors for substituted piperidine synthesis, has been established via Stille-Migita coupling, 6π-azaelectrocyclization, and aminoacetal formation from readily prepared vinylstannanes,

Development of highly stereoselective asymmetric 6π- azaelectrocyclization of conformationally flexible linear 1-azatrienes. From determination of multifunctional chiral amines, 7-alkyl cis-1-amino-2-indanols, to application as a new synthetic strategy: Formal synthesis of 20-epiuleine

The highly stereoselective asymmetric 6π-azaelectrocyclization was achieved as a general synthetic method based on the reaction between the (E)-3-carbonyl-2,4,6-trienal compounds and the (-)-7-alkyl-cis-l-amino-2-indanol derivatives which are effective chiral amines. The 7-alkyl-substituted 2-indanol moiety of the cyclized products was efficiently removed by the novel manganese dioxide oxidation under remarkably mild conditions, and the method was successfully applied to the formal synthesis of optically active 20-epiuleine.

Highly stereoselective asymmetric 6π-azaelectrocyclization utilizing the novel 7-alkyl substituted cis-1-amino-2-indanols: Formal synthesis of 20-epiuleine

Highly stereoselective asymmetric 6π-azaelectrocyclization was achieved with generality, based on the reaction between the (E)-3-carbonyl-2,4,6-trienal compounds and the (-)-7-alkyl-cis-1-amino-2-indanol derivatives as the effective novel chiral amines. F