(2S)-methyl 2-(((((4R,5R,7R,8R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

Base Information

Chemical Name:(2S)-methyl 2-(((((4R,5R,7R,8R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
CAS No.:1378912-65-2
Molecular Formula:C₂₃H₂₉N₆O₉P
Molecular Weight:564.492
Hs Code.:

Synonyms:(2S)-methyl 2-(((((4R,5R,7R,8R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

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Chemical Property of (2S)-methyl 2-(((((4R,5R,7R,8R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

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Technology Process of (2S)-methyl 2-(((((4R,5R,7R,8R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

There total 15 articles about (2S)-methyl 2-(((((4R,5R,7R,8R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1378912-07-2
(4R,5R,7R,8R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-7-(hydroxymethyl)-1,6-dioxaspiro[3.4]octan-8-ol

: 142629-80-9
phenyl methoxyalaninyl phosphorochloridate

: 1378912-65-2
(2S)-methyl 2-(((((4R,5R,7R,8R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

Guidance literature:: With 1-methyl-1H-imidazole; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1378911-97-7
C₃₃H₄₉N₅O₇Si₂

: 1378912-65-2
(2S)-methyl 2-(((((4R,5R,7R,8R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; 4-methylmorpholine N-oxide / osmium(VIII) oxide / tert-butyl alcohol; tetrahydrofuran / 16 h / 20 °C

2.1: sodium periodate / water; tetrahydrofuran / 3 h / 20 °C

2.2: 1 h / 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

4.1: ammonium fluoride / methanol / 5 h / 60 °C

5.1: sodium methylate; methanol / 20 h / 20 °C

6.1: 1-methyl-1H-imidazole / dichloromethane / 3 h / 20 °C

With 1-methyl-1H-imidazole; methanol; ammonium fluoride; sodium periodate; water; sodium methylate; sodium hydride; 4-methylmorpholine N-oxide; osmium(VIII) oxide; In tetrahydrofuran; methanol; dichloromethane; water; mineral oil; tert-butyl alcohol;

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 1378912-65-2
(2S)-methyl 2-(((((4R,5R,7R,8R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-8-hydroxy-1,6-dioxaspiro[3.4]octan-7-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: trimethylsilyl trifluoromethanesulfonate; DBN / acetonitrile / 21 h / 0 - 65 °C

2.1: sodium methylate / 24 h / 20 °C

3.1: pyridine / 16 h / 20 °C

4.1: pyridine / dichloromethane / 5 h / 20 °C

5.1: water; 4-methylmorpholine N-oxide / osmium(VIII) oxide / tert-butyl alcohol; tetrahydrofuran / 16 h / 20 °C

6.1: sodium periodate / water; tetrahydrofuran / 3 h / 20 °C

6.2: 1 h / 0 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

8.1: ammonium fluoride / methanol / 5 h / 60 °C

9.1: sodium methylate; methanol / 20 h / 20 °C

10.1: 1-methyl-1H-imidazole / dichloromethane / 3 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; methanol; ammonium fluoride; sodium periodate; trimethylsilyl trifluoromethanesulfonate; DBN; water; sodium methylate; sodium hydride; 4-methylmorpholine N-oxide; pyridine; osmium(VIII) oxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; mineral oil; tert-butyl alcohol;