Acetic acid (R)-2-methanesulfonyloxy-1-{(4S,5R)-5-[(S)-2-methanesulfonyloxy-1-(toluene-4-sulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl ester

Base Information

Chemical Name:Acetic acid (R)-2-methanesulfonyloxy-1-{(4S,5R)-5-[(S)-2-methanesulfonyloxy-1-(toluene-4-sulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl ester
CAS No.:914982-65-3
Molecular Formula:C₂₀H₃₁NO₁₂S₃
Molecular Weight:573.664
Hs Code.:

Acetic acid (R)-2-methanesulfonyloxy-1-{(4S,5R)-5-[(S)-2-methanesulfonyloxy-1-(toluene-4-sulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl ester

Synonyms:Acetic acid (R)-2-methanesulfonyloxy-1-{(4S,5R)-5-[(S)-2-methanesulfonyloxy-1-(toluene-4-sulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl ester

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Chemical Property of Acetic acid (R)-2-methanesulfonyloxy-1-{(4S,5R)-5-[(S)-2-methanesulfonyloxy-1-(toluene-4-sulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl ester

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Technology Process of Acetic acid (R)-2-methanesulfonyloxy-1-{(4S,5R)-5-[(S)-2-methanesulfonyloxy-1-(toluene-4-sulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl ester

There total 10 articles about Acetic acid (R)-2-methanesulfonyloxy-1-{(4S,5R)-5-[(S)-2-methanesulfonyloxy-1-(toluene-4-sulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 914982-64-2
(R)-2-hydroxy-1-((4S,5R)-5-((S)-2-hydroxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

: 124-63-0
methanesulfonyl chloride

: 914982-65-3
Acetic acid (R)-2-methanesulfonyloxy-1-{(4S,5R)-5-[(S)-2-methanesulfonyloxy-1-(toluene-4-sulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl ester

Guidance literature:: With pyridine; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.tet.2006.08.035

Reference yield:

: 914982-59-5
Acetic acid (R)-1-[(4S,5R)-5-((S)-1-amino-2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-benzyloxy-ethyl ester

: 914982-65-3
Acetic acid (R)-2-methanesulfonyloxy-1-{(4S,5R)-5-[(S)-2-methanesulfonyloxy-1-(toluene-4-sulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / pyridine / 3 h / 0 - 20 °C

2: 83 percent / hydrogen / Pd/C / methanol / 24 h / 20 °C / atmospheric pressure

3: 91 percent / pyridine / 3 h / 0 - 20 °C

With pyridine; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/j.tet.2006.08.035

Reference yield:

: 914982-58-4
(R)-1-((4S,5R)-5-((S)-1-azido-2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(benzyloxy)ethyl acetate

: 914982-65-3
Acetic acid (R)-2-methanesulfonyloxy-1-{(4S,5R)-5-[(S)-2-methanesulfonyloxy-1-(toluene-4-sulfonylamino)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / hydrogen / Lindlar's catalyst / methanol / 4 h / 20 °C / 760 Torr

2: 86 percent / pyridine / 3 h / 0 - 20 °C

3: 83 percent / hydrogen / Pd/C / methanol / 24 h / 20 °C / atmospheric pressure

4: 91 percent / pyridine / 3 h / 0 - 20 °C

With pyridine; hydrogen; palladium on activated charcoal; Lindlar's catalyst; In methanol;
DOI:10.1016/j.tet.2006.08.035