(R)-2-hydroxy-1-((4S,5R)-5-((S)-2-hydroxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

Base Information

Chemical Name:(R)-2-hydroxy-1-((4S,5R)-5-((S)-2-hydroxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate
CAS No.:914982-64-2
Molecular Formula:C₁₈H₂₇NO₈S
Molecular Weight:417.48
Hs Code.:

Synonyms:(R)-2-hydroxy-1-((4S,5R)-5-((S)-2-hydroxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

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Chemical Property of (R)-2-hydroxy-1-((4S,5R)-5-((S)-2-hydroxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

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Technology Process of (R)-2-hydroxy-1-((4S,5R)-5-((S)-2-hydroxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

There total 9 articles about (R)-2-hydroxy-1-((4S,5R)-5-((S)-2-hydroxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 914982-60-8
(R)-2-benzyloxy-1-((4S,5R)-5-((S)-2-(benzyloxy)-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

: 914982-64-2
(R)-2-hydroxy-1-((4S,5R)-5-((S)-2-hydroxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 24h; atmospheric pressure;
DOI:10.1016/j.tet.2006.08.035

Reference yield:

: 914982-58-4
(R)-1-((4S,5R)-5-((S)-1-azido-2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(benzyloxy)ethyl acetate

: 914982-64-2
(R)-2-hydroxy-1-((4S,5R)-5-((S)-2-hydroxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / hydrogen / Lindlar's catalyst / methanol / 4 h / 20 °C / 760 Torr

2: 86 percent / pyridine / 3 h / 0 - 20 °C

3: 83 percent / hydrogen / Pd/C / methanol / 24 h / 20 °C / atmospheric pressure

With pyridine; hydrogen; palladium on activated charcoal; Lindlar's catalyst; In methanol;
DOI:10.1016/j.tet.2006.08.035

Reference yield:

: 914982-59-5
Acetic acid (R)-1-[(4S,5R)-5-((S)-1-amino-2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-benzyloxy-ethyl ester

: 914982-64-2
(R)-2-hydroxy-1-((4S,5R)-5-((S)-2-hydroxy-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / pyridine / 3 h / 0 - 20 °C

2: 83 percent / hydrogen / Pd/C / methanol / 24 h / 20 °C / atmospheric pressure

With pyridine; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/j.tet.2006.08.035