(S)-1-(4-(6-acetyl-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)-3-cyclopropylurea

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Chemical Name:(S)-1-(4-(6-acetyl-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)-3-cyclopropylurea
CAS No.:1402550-92-8
Molecular Formula:C₂₃H₂₈N₆O₃
Molecular Weight:436.514
Hs Code.:

Synonyms:(S)-1-(4-(6-acetyl-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)-3-cyclopropylurea

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Chemical Property of (S)-1-(4-(6-acetyl-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)-3-cyclopropylurea

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Technology Process of (S)-1-(4-(6-acetyl-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)-3-cyclopropylurea

There total 8 articles about (S)-1-(4-(6-acetyl-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)-3-cyclopropylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1402550-81-5
(S)-1-cyclopropyl-3-(4-(2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea

: 75-36-5
acetyl chloride

: 1402550-92-8
(S)-1-(4-(6-acetyl-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)-3-cyclopropylurea

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 171364-83-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene

: 1402550-92-8
(S)-1-(4-(6-acetyl-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 7 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 3 h / 90 °C

2: triethylamine / N,N-dimethyl-formamide / 50 °C

3: hydrogen / palladium 10% on activated carbon / ethanol

4: dichloromethane / 20 °C

5: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

6: ammonia / methanol

7: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; ammonia; hydrogen; sodium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 903129-71-5
tert-butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate

: 1402550-92-8
(S)-1-(4-(6-acetyl-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 7 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 3 h / 90 °C

2: triethylamine / N,N-dimethyl-formamide / 50 °C

3: hydrogen / palladium 10% on activated carbon / ethanol

4: dichloromethane / 20 °C

5: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

6: ammonia / methanol

7: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; ammonia; hydrogen; sodium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;