(R)-4-bromo-α-N-trityltryptophan trityl ester

Base Information

Chemical Name:(R)-4-bromo-α-N-trityltryptophan trityl ester
CAS No.:219943-50-7
Molecular Formula:C₄₉H₃₉BrN₂O₂
Molecular Weight:767.765
Hs Code.:

Synonyms:(R)-4-bromo-α-N-trityltryptophan trityl ester

Suppliers and Price of (R)-4-bromo-α-N-trityltryptophan trityl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-4-bromo-α-N-trityltryptophan trityl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-4-bromo-α-N-trityltryptophan trityl ester

There total 11 articles about (R)-4-bromo-α-N-trityltryptophan trityl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 596-43-0
bromo-triphenyl-methane

: 219943-61-0
(R)-4-bromotryptophan

: 219943-50-7
(R)-4-bromo-α-N-trityltryptophan trityl ester

Guidance literature:: With triethylamine; In chloroform; N,N-dimethyl-formamide; 1.) 0 deg C, 15 min, 2.) room temperature, 2 h;
DOI:10.1021/jo981723s

Reference yield:

: 52488-36-5
4-bromo-1H-indole

: 219943-50-7
(R)-4-bromo-α-N-trityltryptophan trityl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 31.0 g / pyridinium bromide perbromide / pyridine / 0.25 h / 0 °C

2: Et₃N, DMAP / tetrahydrofuran / 14 h

3: 1.) n-BuLi / 1.) THF, -78 deg C, 90 min, 2.) THF, -75 deg C, 4 h

4: 99 percent / NaOMe / tetrahydrofuran / 1 h / Ambient temperature

5: 91 percent / DMAO, BH₃*THF / tetrahydrofuran / 72 h / 0 °C

6: 95 percent / DMAP / tetrahydrofuran / 4 h / Ambient temperature

7: 86 percent / 1M HCl / ethyl acetate / 1.) 0 deg C to room temperature, 1 h, 2.) room temperature, 4 h

8: 1.) NCS, DMS, 2.) Et₃N / 1.) toluene, -25 deg C, 6 h, 2.) -25 deg C, 10 min; room temperature, 1 h

9: 69 percent / 2-methyl-2-butene, NaClO₂, NaH₂PO₄ / acetonitrile; 2-methyl-propan-2-ol; H₂O / 0.17 h / 0 °C

10: 1.) Et₃SiH, TMSOTf, 2.) 1M HCl / 1.) DCE, reflux, 1 h, 2.) reflux, 2 h

11: 90 percent / Et₃N / dimethylformamide; CHCl₃ / 1.) 0 deg C, 15 min, 2.) room temperature, 2 h

With hydrogenchloride; triethylsilane; dmap; sodium chlorite; sodium dihydrogenphosphate; N-chloro-succinimide; n-butyllithium; borane-THF; 2-methyl-but-2-ene; 2,3-dimercapto-succinic acid; trimethylsilyl trifluoromethanesulfonate; sodium methylate; pyridinium hydrobromide perbromide; triethylamine; In tetrahydrofuran; pyridine; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo981723s

Reference yield:

: 219943-37-0
3,4-dibromo-1H-indole

: 219943-50-7
(R)-4-bromo-α-N-trityltryptophan trityl ester

Guidance literature:: Multi-step reaction with 10 steps

1: Et₃N, DMAP / tetrahydrofuran / 14 h

2: 1.) n-BuLi / 1.) THF, -78 deg C, 90 min, 2.) THF, -75 deg C, 4 h

3: 99 percent / NaOMe / tetrahydrofuran / 1 h / Ambient temperature

4: 91 percent / DMAO, BH₃*THF / tetrahydrofuran / 72 h / 0 °C

5: 95 percent / DMAP / tetrahydrofuran / 4 h / Ambient temperature

6: 86 percent / 1M HCl / ethyl acetate / 1.) 0 deg C to room temperature, 1 h, 2.) room temperature, 4 h

7: 1.) NCS, DMS, 2.) Et₃N / 1.) toluene, -25 deg C, 6 h, 2.) -25 deg C, 10 min; room temperature, 1 h

8: 69 percent / 2-methyl-2-butene, NaClO₂, NaH₂PO₄ / acetonitrile; 2-methyl-propan-2-ol; H₂O / 0.17 h / 0 °C

9: 1.) Et₃SiH, TMSOTf, 2.) 1M HCl / 1.) DCE, reflux, 1 h, 2.) reflux, 2 h

10: 90 percent / Et₃N / dimethylformamide; CHCl₃ / 1.) 0 deg C, 15 min, 2.) room temperature, 2 h

With hydrogenchloride; triethylsilane; dmap; sodium chlorite; sodium dihydrogenphosphate; N-chloro-succinimide; n-butyllithium; borane-THF; 2-methyl-but-2-ene; 2,3-dimercapto-succinic acid; trimethylsilyl trifluoromethanesulfonate; sodium methylate; triethylamine; In tetrahydrofuran; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo981723s