C₂₇H₂₈Cl₂N₆O₅S

Base Information

Chemical Name:C₂₇H₂₈Cl₂N₆O₅S
CAS No.:1365992-37-5
Molecular Formula:C₂₇H₂₈Cl₂N₆O₅S
Molecular Weight:619.529
Hs Code.:

C<sub>27</sub>H<sub>28</sub>Cl<sub>2</sub>N<sub>6</sub>O<sub>5</sub>S

Synonyms:C₂₇H₂₈Cl₂N₆O₅S

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Chemical Property of C₂₇H₂₈Cl₂N₆O₅S

Chemical Property:

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Technology Process of C₂₇H₂₈Cl₂N₆O₅S

There total 12 articles about C₂₇H₂₈Cl₂N₆O₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 1365992-37-5
C₂₇H₂₈Cl₂N₆O₅S

Guidance literature:: Multi-step reaction with 9 steps

1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2.2: NH₂ cartridge

3.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

4.1: thionyl chloride / 56 h / 90 °C

5.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

5.2: 1.5 h / 90 °C

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

7.1: ozone / dichloromethane; methanol / 0.17 h / -78 °C

7.2: -78 - 20 °C / Inert atmosphere

8.1: sodium cyanoborohydride; acetic acid / dichloromethane; methanol / 2 h

9.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 80 °C / Inert atmosphere

With pyridine; thionyl chloride; diphenyl phosphoryl azide; sodium cyanoborohydride; sodium carbonate; caesium carbonate; ozone; acetic acid; triethylamine; thiourea; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol; toluene;

Reference yield:

: 354112-08-6
tert-butyl N-tert-butoxycarbonyl-N-(6-chloropyrimidin-4-yl)carbamate

: 1365992-37-5
C₂₇H₂₈Cl₂N₆O₅S

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / 4 h / 70 °C

2: hydrogen / 5%-palladium/activated carbon / ethyl acetate; industrial methylated spirits / 18 h / 20 °C

3: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 80 °C / Inert atmosphere

With sodium azide; hydrogen; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5%-palladium/activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; industrial methylated spirits; ethyl acetate;

Reference yield:

: 1258298-01-9
2,6-dichloro-4-iodo-benzoic acid

: 1365992-37-5
C₂₇H₂₈Cl₂N₆O₅S

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

3.1: thionyl chloride / 56 h / 90 °C

4.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

4.2: 1.5 h / 90 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

6.1: ozone / dichloromethane; methanol / 0.17 h / -78 °C

6.2: -78 - 20 °C / Inert atmosphere

7.1: sodium cyanoborohydride; acetic acid / dichloromethane; methanol / 2 h

8.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 80 °C / Inert atmosphere

With pyridine; thionyl chloride; sodium cyanoborohydride; sodium carbonate; caesium carbonate; ozone; acetic acid; triethylamine; thiourea; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol;