{4-[4-(6-aminopyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-3,5-dichlorophenyl}-methanol formate salt

Base Information

Chemical Name:{4-[4-(6-aminopyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-3,5-dichlorophenyl}-methanol formate salt
CAS No.:1365990-62-0
Molecular Formula:CH₂O₂*C₁₇H₁₂Cl₂N₆OS
Molecular Weight:465.32
Hs Code.:

Synonyms:{4-[4-(6-aminopyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-3,5-dichlorophenyl}-methanol formate salt

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Chemical Property of {4-[4-(6-aminopyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-3,5-dichlorophenyl}-methanol formate salt

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Technology Process of {4-[4-(6-aminopyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-3,5-dichlorophenyl}-methanol formate salt

There total 12 articles about {4-[4-(6-aminopyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-3,5-dichlorophenyl}-methanol formate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 64-18-6
formic acid

: 1365992-37-5
C₂₇H₂₈Cl₂N₆O₅S

: 1365990-62-0
{4-[4-(6-aminopyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-3,5-dichlorophenyl}-methanol formate salt

Guidance literature:: C₂₇H₂₈Cl₂N₆O₅S; With hydrogenchloride; In isopropyl alcohol; at 50 ℃; for 18h; Inert atmosphere;

formic acid; In methanol; water;

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 1365990-62-0
{4-[4-(6-aminopyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-3,5-dichlorophenyl}-methanol formate salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2.2: NH₂ cartridge

3.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

4.1: thionyl chloride / 56 h / 90 °C

5.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

5.2: 1.5 h / 90 °C

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

7.1: ozone / dichloromethane; methanol / 0.17 h / -78 °C

7.2: -78 - 20 °C / Inert atmosphere

8.1: sodium cyanoborohydride; acetic acid / dichloromethane; methanol / 2 h

9.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 80 °C / Inert atmosphere

10.1: hydrogenchloride / isopropyl alcohol / 18 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; thionyl chloride; diphenyl phosphoryl azide; sodium cyanoborohydride; sodium carbonate; caesium carbonate; ozone; acetic acid; triethylamine; thiourea; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol; toluene;

Reference yield:

: 1258298-01-9
2,6-dichloro-4-iodo-benzoic acid

: 1365990-62-0
{4-[4-(6-aminopyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-3,5-dichlorophenyl}-methanol formate salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

3.1: thionyl chloride / 56 h / 90 °C

4.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

4.2: 1.5 h / 90 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

6.1: ozone / dichloromethane; methanol / 0.17 h / -78 °C

6.2: -78 - 20 °C / Inert atmosphere

7.1: sodium cyanoborohydride; acetic acid / dichloromethane; methanol / 2 h

8.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 80 °C / Inert atmosphere

9.1: hydrogenchloride / isopropyl alcohol / 18 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; thionyl chloride; sodium cyanoborohydride; sodium carbonate; caesium carbonate; ozone; acetic acid; triethylamine; thiourea; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol;