Technology Process of 2-(1,1-difluoro-2-((2R,3R,4S,5R,6R)-3,4,5,6-tetrakis(benzyloxy)tetrahydro-2H-pyran-2-yl)ethylsulfonyl)pyridine
There total 3 articles about 2-(1,1-difluoro-2-((2R,3R,4S,5R,6R)-3,4,5,6-tetrakis(benzyloxy)tetrahydro-2H-pyran-2-yl)ethylsulfonyl)pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -98 ℃;
for 0.0833333h;
Inert atmosphere;
DOI:10.1002/anie.201007594
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium hydroxide
2: ammonium heptamolybdate tetrahydrate; dihydrogen peroxide / methanol / 36 h / 20 °C
3: lithium hexamethyldisilazane / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 0.08 h / -98 °C / Inert atmosphere
With
ammonium heptamolybdate tetrahydrate; dihydrogen peroxide; potassium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1002/anie.201007594
- Guidance literature:
-
Multi-step reaction with 2 steps
1: ammonium heptamolybdate tetrahydrate; dihydrogen peroxide / methanol / 36 h / 20 °C
2: lithium hexamethyldisilazane / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 0.08 h / -98 °C / Inert atmosphere
With
ammonium heptamolybdate tetrahydrate; dihydrogen peroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1002/anie.201007594
