1-(4-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Base Information

• Chemical Name: 1-(4-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
• CAS No.: 122551-51-3
• Molecular Formula: C₁₇H₉F₄NO₄
• Molecular Weight: 367.256

Synonyms:1-(4-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Chemical Property of 1-(4-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Chemical Property:

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Technology Process of 1-(4-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

There total 4 articles about 1-(4-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-(4-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (122551-48-8) → 1-(4-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (122551-51-3)

Guidance literature:

With sulfuric acid; In water; acetic acid; Heating;

DOI:10.1002/jps.2600780716

Reference yield:

4-difluoromethoxyaniline (22236-10-8) → 1-(4-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (122551-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / ethanol / Ambient temperature

2: 70 percent / Na₂CO₃ / dimethylformamide

3: 82 percent / conc. H₂SO₄ / acetic acid; H₂O / Heating

With sulfuric acid; sodium carbonate; In ethanol; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1002/jps.2600780716

Reference yield:

α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester (101799-75-1) → 1-(4-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (122551-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / ethanol / Ambient temperature

2: 70 percent / Na₂CO₃ / dimethylformamide

3: 82 percent / conc. H₂SO₄ / acetic acid; H₂O / Heating

With sulfuric acid; sodium carbonate; In ethanol; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1002/jps.2600780716

upstream raw materials:

1-(4-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

4-difluoromethoxyaniline

α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester

(Z)-3-(4-Difluoromethoxy-phenylamino)-2-(2,4,5-trifluoro-benzoyl)-acrylic acid ethyl ester

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