α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester

Base Information

Chemical Name:α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester
CAS No.:101799-75-1
Molecular Formula:C₁₄H₁₃F₃O₄
Molecular Weight:302.25
Hs Code.:2918999090

Synonyms:α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester

Suppliers and Price of α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester

Chemical Property:

Boiling Point:397.1±42.0 °C(Predicted)
Density:1.281±0.06 g/cm3(Predicted)

Purity/Quality:: ≥98% ^*data from raw suppliers

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Technology Process of α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester

There total 4 articles about α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98349-24-7
ethyl 2,4,5-trifluorobenzoylacetate

: 122-51-0
orthoformic acid triethyl ester

: 101799-75-1
α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester

Guidance literature:: With acetic anhydride; for 2h; Heating;

Reference yield:

: 88419-56-1
2,4,5-trifluorobenzoyl chloride

: 101799-75-1
α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Ph₃CH; n-BuLi / tetrahydrofuran

1.2: 100 percent / tetrahydrofuran / 1 h / 20 °C

2.1: Ac₂O / 2 h / 130 °C

With n-butyllithium; triphenylmethane; acetic anhydride; In tetrahydrofuran; 1.1: Metallation / 1.2: Acetylation / 2.1: Condensation;
DOI:10.1021/jm990015b

Reference yield:

: 446-17-3
2,4,5-trifluorobenzoic acid

: 101799-75-1
α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 3 h / 60 °C

2.1: magnesium chloride; triethylamine / toluene; tetrahydrofuran / 1 h / 0 - 50 °C / Large scale

3.1: 0.5 h / 140 °C

3.2: 12 h / 140 °C

With thionyl chloride; triethylamine; magnesium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op0600557