ethyl N-(3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydro-1H-2-pyrrolyl)oxamate

Base Information

• Chemical Name: ethyl N-(3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydro-1H-2-pyrrolyl)oxamate
• CAS No.: 106727-64-4
• Molecular Formula: C₁₈H₁₉N₃O₅
• Molecular Weight: 357.366

Synonyms:ethyl N-(3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydro-1H-2-pyrrolyl)oxamate

Chemical Property of ethyl N-(3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydro-1H-2-pyrrolyl)oxamate

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Technology Process of ethyl N-(3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydro-1H-2-pyrrolyl)oxamate

There total 1 articles about ethyl N-(3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydro-1H-2-pyrrolyl)oxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Ethyl oxalyl chloride (4755-77-5) + 2-amino-3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydropyrrole (83361-95-9) → ethyl N-(3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydro-1H-2-pyrrolyl)oxamate (106727-64-4)

Guidance literature:

With pyridine; at 50 - 53 ℃; for 1h;

Reference yield: 56.0%

ethyl N-(3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydro-1H-2-pyrrolyl)oxamate (106727-64-4) + cyanoacetic acid amide (107-91-5) → 4-Amino-2-carbamoylmethyl-5-phenyl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid ethyl ester (106727-75-7) + 2-amino-3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydropyrrole (83361-95-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 65 - 70 ℃; for 8h;

Reference yield: 40.0%

ethyl N-(3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydro-1H-2-pyrrolyl)oxamate (106727-64-4) + methyl 2-cyanoacetate (105-34-0) → 4-Amino-2-methoxycarbonylmethyl-5-phenyl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid ethyl ester (106727-73-5) + 2-amino-3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydropyrrole (83361-95-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 65 - 70 ℃; for 8h;

upstream raw materials:

Ethyl oxalyl chloride

2-amino-3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydropyrrole

Downstream raw materials:

4-Amino-2-ethoxycarbonylmethyl-5-phenyl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid ethyl ester

2-amino-3-cyano-1-ethoxycarbonyl-4-phenyl-4,5-dihydropyrrole

4-Amino-2-(2-oxo-2-pyrrolidin-1-yl-ethyl)-5-phenyl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid ethyl ester

4-Amino-2-methoxycarbonylmethyl-5-phenyl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid ethyl ester

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