(+)-tert-butyl-{(S)-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane

Base Information

Chemical Name:(+)-tert-butyl-{(S)-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane
CAS No.:496035-38-2
Molecular Formula:C₂₁H₃₆O₄Si
Molecular Weight:380.6
Hs Code.:

Synonyms:(+)-tert-butyl-{(S)-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane

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Chemical Property of (+)-tert-butyl-{(S)-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane

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Technology Process of (+)-tert-butyl-{(S)-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane

There total 13 articles about (+)-tert-butyl-{(S)-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 496766-52-0
(+)-(2S,3S,4S)-1-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4-dimethylpentan-3-ol

: 496035-38-2
(+)-tert-butyl-{(S)-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jo048534w

Reference yield:

: 182193-69-7
(S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one

: 496035-38-2
(+)-tert-butyl-{(S)-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: dicyclohexylboron chloride; triethylamine / diethyl ether / 2 h / 0 °C

1.2: diethyl ether / -78 - 0 °C

2.1: dicyclohexylboron chloride; triethylamine / diethyl ether

2.2: LiBH₄ / diethyl ether

3.1: 100 percent / imidazole / CH₂Cl₂ / 0.5 h

4.1: 84 percent / DDQ / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; dicyclohexylboron chloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; dichloromethane;
DOI:10.1021/jo048534w

Reference yield:

: 496035-35-9
(2S,4S)-1-hydroxy-5-(p-methoxybenzyloxy)-2,4-dimethylpentan-3-one

: 496035-38-2
(+)-tert-butyl-{(S)-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexylboron chloride; triethylamine / diethyl ether

1.2: LiBH₄ / diethyl ether

2.1: 100 percent / imidazole / CH₂Cl₂ / 0.5 h

3.1: 84 percent / DDQ / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; dicyclohexylboron chloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; dichloromethane;
DOI:10.1021/jo048534w