3,11-bis(tert-butyldimethylsilyloxy)-14-[3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-2,12-dimethoxy-6H-[1]-benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Base Information

Chemical Name:3,11-bis(tert-butyldimethylsilyloxy)-14-[3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-2,12-dimethoxy-6H-[1]-benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one
CAS No.:1454845-03-4
Molecular Formula:C₄₆H₆₃NO₈Si₃
Molecular Weight:842.265
Hs Code.:

3,11-bis(tert-butyldimethylsilyloxy)-14-[3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-2,12-dimethoxy-6H-[1]-benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Synonyms:3,11-bis(tert-butyldimethylsilyloxy)-14-[3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-2,12-dimethoxy-6H-[1]-benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

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Chemical Property of 3,11-bis(tert-butyldimethylsilyloxy)-14-[3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-2,12-dimethoxy-6H-[1]-benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

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Technology Process of 3,11-bis(tert-butyldimethylsilyloxy)-14-[3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-2,12-dimethoxy-6H-[1]-benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

There total 5 articles about 3,11-bis(tert-butyldimethylsilyloxy)-14-[3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-2,12-dimethoxy-6H-[1]-benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 149379-26-0
3,11-dihydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

: 1454845-03-4
3,11-bis(tert-butyldimethylsilyloxy)-14-[3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-2,12-dimethoxy-6H-[1]-benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm400719y

Reference yield:

: 660397-47-7
8,9-dihydro-3,11-diisopropoxy-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

: 1454845-03-4
3,11-bis(tert-butyldimethylsilyloxy)-14-[3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-2,12-dimethoxy-6H-[1]-benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 24 h / 0 °C

2: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver(l) oxide / 1,2-dimethoxyethane / 24 h / 85 °C / Inert atmosphere

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 18 h / Inert atmosphere; Reflux

4: boron trichloride / dichloromethane / 6 h / -78 - 20 °C / Inert atmosphere

5: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

With 1H-imidazole; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trichloride; cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm400719y

Reference yield:

: 660397-48-8
14-bromo-3,11-diisopropoxy-2,12-dimethoxy-8,9-dihydro-6H-[1]benzopyrano[4’,3’:4,5]pyrrolo[2,1-a]isoquinolin-6-one

: 1454845-03-4
3,11-bis(tert-butyldimethylsilyloxy)-14-[3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-2,12-dimethoxy-6H-[1]-benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver(l) oxide / 1,2-dimethoxyethane / 24 h / 85 °C / Inert atmosphere

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 18 h / Inert atmosphere; Reflux

3: boron trichloride / dichloromethane / 6 h / -78 - 20 °C / Inert atmosphere

4: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trichloride; cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm400719y