ethyl 4-chloro-3-methyl-5-[({p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl}acetyl)imino]-3-isothiazoline-2-acetate

Base Information

Chemical Name:ethyl 4-chloro-3-methyl-5-[({p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl}acetyl)imino]-3-isothiazoline-2-acetate
CAS No.:189291-55-2
Molecular Formula:C₂₃H₂₀ClF₃N₂O₄S
Molecular Weight:512.937
Hs Code.:

Synonyms:ethyl 4-chloro-3-methyl-5-[({p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl}acetyl)imino]-3-isothiazoline-2-acetate

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Chemical Property of ethyl 4-chloro-3-methyl-5-[({p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl}acetyl)imino]-3-isothiazoline-2-acetate

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Technology Process of ethyl 4-chloro-3-methyl-5-[({p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl}acetyl)imino]-3-isothiazoline-2-acetate

There total 5 articles about ethyl 4-chloro-3-methyl-5-[({p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl}acetyl)imino]-3-isothiazoline-2-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 105-36-2
ethyl bromoacetate

: 174520-35-5
N-(4-chloro-3-methyl-5-isothiazolyl)-2-[p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl]acetamide

: 189291-55-2
ethyl 4-chloro-3-methyl-5-[({p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl}acetyl)imino]-3-isothiazoline-2-acetate

: N-(4-chloro-3-methyl-5-isothiazolyl)-N-({p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl}acetyl)glycine ethyl ester

Guidance literature:: With sodium hydroxide; benzyltriethylammonium bromide; potassium carbonate; In dichloromethane; for 48h; Ambient temperature;
DOI:10.1021/jf960679j

Reference yield:

: 98-56-6
4-chlorobenzotrifluoride

: 189291-55-2
ethyl 4-chloro-3-methyl-5-[({p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl}acetyl)imino]-3-isothiazoline-2-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / NaH / dimethylsulfoxide / 16 h / 160 - 175 °C

2: thionyl chloride / CH₂Cl₂ / 2 h / Heating

3: xylene / 2 h / Heating

4: 39 percent / K₂CO₂, triethylbenzylammonium bromide, aq. NaOH / CH₂Cl₂ / 48 h / Ambient temperature

With sodium hydroxide; thionyl chloride; benzyltriethylammonium bromide; sodium hydride; potassium carbonate; In dichloromethane; dimethyl sulfoxide; xylene;
DOI:10.1021/jf960679j

Reference yield:

: 148401-41-6
{p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl}acetic acid

: 189291-55-2
ethyl 4-chloro-3-methyl-5-[({p-[(α,α,α-trifluoro-p-tolyl)oxy]phenyl}acetyl)imino]-3-isothiazoline-2-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / CH₂Cl₂ / 2 h / Heating

2: xylene / 2 h / Heating

3: 39 percent / K₂CO₂, triethylbenzylammonium bromide, aq. NaOH / CH₂Cl₂ / 48 h / Ambient temperature

With sodium hydroxide; thionyl chloride; benzyltriethylammonium bromide; potassium carbonate; In dichloromethane; xylene;
DOI:10.1021/jf960679j