1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester

Base Information

• Chemical Name: 1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester
• CAS No.: 124461-08-1
• Molecular Formula: C₁₆H₂₃NO₃
• Molecular Weight: 277.364
• Mol file: 124461-08-1.mol

Synonyms:1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester

Chemical Property of 1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester

There total 1 articles about 1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-methoxyphenethyl bromide (14425-64-0) + methyl piperidine-4-carboxylate hydrochloride (7462-86-4) → 1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester (124461-08-1)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 17h; Heating;

DOI:10.1021/jo00291a063

Reference yield:

2-thienyl lithium (2786-07-4) + 1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester (124461-08-1) → α-[1-[2-(4-Methoxyphenyl)ethyl]-4-piperidinyl]-α-(thiophene-2-yl)-2-thiophenemethanol

Guidance literature:

With ammonium chloride; In tetrahydrofuran;

Reference yield:

1,3-Benzothiazole (95-16-9) + 1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester (124461-08-1) → [2-benzothiazolyl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone (152936-86-2)

Guidance literature:

With n-butyllithium; ammonium chloride; In tetrahydrofuran; hexane;

upstream raw materials:

4-methoxyphenethyl bromide

methyl piperidine-4-carboxylate hydrochloride

Downstream raw materials:

[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone

[2-benzothiazolyl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone