[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone

Base Information

Chemical Name:[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone
CAS No.:124461-07-0
Molecular Formula:C₂₉H₃₀FN₃O₂
Molecular Weight:471.575
Hs Code.:
DSSTox Substance ID:DTXSID601112537
Nikkaji Number:J284.235A
Pharos Ligand ID:LXYPMXVH85QV
ChEMBL ID:CHEMBL95051

Synonyms:MDL-28163;CHEMBL95051;[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone;D0A1DE;SCHEMBL9196398;DIPBPGRFGZKMEF-UHFFFAOYSA-N;DTXSID601112537;BDBM50175511;1-(4-Fluorobenzyl)-2-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinylcarbonyl]-1H-benzimidazole;[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-yl]-{1-[2-(4-methoxy-phenyl)-ethyl]-piperidin-4-yl}-methanone;124461-07-0

Suppliers and Price of [1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of [1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone

Chemical Property:

XLogP3:5.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:471.23220537
Heavy Atom Count:35
Complexity:669

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)CCN2CCC(CC2)C(=O)C3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F

Technology Process of [1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone

There total 9 articles about [1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 14425-64-0
4-methoxyphenethyl bromide

: 124443-71-6
<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>-4-piperidinylmethanone mono(trifluoroacetate)

: 124461-07-0
[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 22h;
DOI:10.1021/jo00291a063

Reference yield:

: 51-17-2,79351-71-6
benzoimidazole

: 124461-07-0
[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, r. t., 30 min 2.) 17h

2: 1.) n-BuLi / 1.) -78 deg C, THF, hexane, 15 min 2.) THF, 15 min, -78 deg C

3: 84 percent / 0.5 h / Ambient temperature

4: 57 percent / K₂CO₃ / dimethylformamide / 22 h / 90 °C

With n-butyllithium; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jo00291a063

Reference yield:

: 7462-86-4
methyl piperidine-4-carboxylate hydrochloride

: 124461-07-0
[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / dimethylformamide / 17 h / 90 °C / Heating

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min 2.) THF, a) 5-10 min, -78 deg C b) without cooling

With n-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1021/jo00291a063