Methyl piperidine-4-carboxylate hydrochloride

Base Information

• Chemical Name: Methyl piperidine-4-carboxylate hydrochloride
• CAS No.: 7462-86-4
• Molecular Formula: C7H13 N O2 . Cl H
• Molecular Weight: 179.647
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30996124
• NSC Number: 402200
• Mol file: 7462-86-4.mol

Synonyms:7462-86-4;methyl piperidine-4-carboxylate hydrochloride;methyl piperidine-4-carboxylate hcl;Methyl Piperidine-4-carboxylate Hydrochloride;methyl 4-piperidinecarboxylate hydrochloride;methyl piperidine-4-carboxylate;hydrochloride;MFCD02667641;methyl 4-piperidinecarboxylate, hcl;Piperidine-4-carboxylic acid methyl ester hydrochloride;methyl isonipecotate hydrochloride;4-Piperidinecarboxylic acid, methyl ester, hydrochloride;methyl piperidine-4-carboxylate hcl salt;METHYL 4-PIPERIDINECARBOXYLIC ESTER HCL;METHYLPIPERIDINE-4-CARBOXYLATEHYDROCHLORIDE;SCHEMBL774514;DTXSID30996124;XAVNWNCTXQDFLF-UHFFFAOYSA-N;isonipecotic acid methyl ester HCl;methyl isonipecotinate hydrochloride;NSC402200;AKOS005259741;CS-W002947;NSC-402200;SY004301;TS-02508;isonipecotic acid methyl ester hydrochloride;A9553;AM20100724;isonipecotic acid methyl ester, hydrochloride;Methyl-piperidine-4-carboxylate hydrochloride;EN300-111045;methyl(piperidin-4-yl)carboxylate hydrochloride;Methyl piperidine-4-carboxylate--hydrogen chloride (1/1);4-Piperidinecarboxylic acid, methyl ester, hydrochloride (1:1);Methyl isonipecotate hydrochloride

Chemical Property of Methyl piperidine-4-carboxylate hydrochloride

Chemical Property:

• Vapor Pressure: 0.0408mmHg at 25°C
• Melting Point: 160°C
• Refractive Index: 1.465
• Boiling Point: 193.8 °C at 760 mmHg
• Flash Point: 89 ºC
• PSA: 38.33000
• Density: 1.06
• LogP: 1.28980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 179.0713064
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-piperidinecarboxylateHCl 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1CCNCC1.Cl

Technology Process of Methyl piperidine-4-carboxylate hydrochloride

There total 3 articles about Methyl piperidine-4-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.57%

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate (124443-68-1) → methyl piperidine-4-carboxylate hydrochloride (7462-86-4)

Guidance literature:

With hydrogenchloride; In dichloromethane; ethyl acetate; at 20 ℃; for 1.5h; Inert atmosphere;

Reference yield: 98.8%

methanol (67-56-1) + isonipecotic acid (498-94-2) → methyl piperidine-4-carboxylate hydrochloride (7462-86-4)

Guidance literature:

With thionyl chloride; at 80 ℃; for 3h;

Reference yield:

isonipecotic acid (498-94-2) → methyl piperidine-4-carboxylate hydrochloride (7462-86-4)

Guidance literature:

In tetrahydrofuran; hydrogenchloride; methanol; water;

upstream raw materials:

methanol

isonipecotic acid

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

Downstream raw materials:

piperidine-4-carboxylic acid hydrazide

1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

1-benzylpiperidine-4-carboxylic acid methyl ester