(S)-2-Benzyloxycarbonylamino-3-(3,5-diiodo-4-methoxy-phenyl)-propionic acid benzyl ester

Base Information

• Chemical Name: (S)-2-Benzyloxycarbonylamino-3-(3,5-diiodo-4-methoxy-phenyl)-propionic acid benzyl ester
• CAS No.: 866114-89-8
• Molecular Formula: C₂₅H₂₃I₂NO₅
• Molecular Weight: 671.27
• Mol file: 866114-89-8.mol

Synonyms:(S)-2-Benzyloxycarbonylamino-3-(3,5-diiodo-4-methoxy-phenyl)-propionic acid benzyl ester

Chemical Property of (S)-2-Benzyloxycarbonylamino-3-(3,5-diiodo-4-methoxy-phenyl)-propionic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Benzyloxycarbonylamino-3-(3,5-diiodo-4-methoxy-phenyl)-propionic acid benzyl ester

There total 3 articles about (S)-2-Benzyloxycarbonylamino-3-(3,5-diiodo-4-methoxy-phenyl)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(S)-2-Benzyloxycarbonylamino-3-(4-hydroxy-3,5-diiodo-phenyl)-propionic acid benzyl ester (866114-87-6) + methyl iodide (74-88-4) → (S)-2-Benzyloxycarbonylamino-3-(3,5-diiodo-4-methoxy-phenyl)-propionic acid benzyl ester (866114-89-8)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Heating;

DOI:10.1021/jo051076m

Reference yield:

benzyl N-carbobenzyloxy-L-tyrosine (5513-40-6) → (S)-2-Benzyloxycarbonylamino-3-(3,5-diiodo-4-methoxy-phenyl)-propionic acid benzyl ester (866114-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / Ag₂SO₄; iodine / methanol / 5 h / 20 °C

2: 86 percent / K₂CO₃ / acetone / 24 h / Heating

With iodine; potassium carbonate; silver sulfate; In methanol; acetone;

DOI:10.1021/jo051076m

Reference yield:

benzyl bromide (100-39-0) → (S)-2-Benzyloxycarbonylamino-3-(3,5-diiodo-4-methoxy-phenyl)-propionic acid benzyl ester (866114-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 28 percent / potassium carbonate / acetone

2: 86 percent / K₂CO₃ / acetone / 24 h / Heating

With potassium carbonate; In acetone;

DOI:10.1021/jo051076m

upstream raw materials:

(S)-2-Benzyloxycarbonylamino-3-(4-hydroxy-3,5-diiodo-phenyl)-propionic acid benzyl ester

methyl iodide

benzyl N-carbobenzyloxy-L-tyrosine

benzyl bromide